Selected Literature

The Legionella Lqs-LvbR regulatory network controls temperature-dependent growth onset and bacterial cell density.
Hochstrasser R, Hilbi H (2022)
Appl Environ Microbiol 88: e0237021

Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection.
Maffei E, Shaidullina A, Burkolter M, Druelle V, Willi L, Estermann F, Michaelis S, Hilbi H, Thaler DS, Harms A (2021)
PLoS Biol. 19: e3001424

Bacterial quorum sensing and phenotypic heterogeneity: how the collective shapes the individual.
Striednig B, Hilbi H (2021)
Trends Microbiol: Online ahead of print

Dictyostelium dynamin superfamily GTPases implicated in vesicle trafficking and host-pathogen interactions.
Katic A, Hüsler D, Letourneur F, Hilbi H (2021)
Front Cell Dev Biol: Online ahead of print

The polar Legionella Icm/Dot T4SS establishes distinct contact sites with the pathogen vacuole membrane.
Böck D, Hüsler D, Steiner B, Medeiros JM, Welin A, Radomska KA, Hardt WD, Pilhofer M, Hilbi H (2021)
mBio 12: e02180-21

Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery.
Striednig B, Lanner U, Niggli S, Katic A, Vormittag S, Brülisauer S, Hochstrasser R, Kaech A, Welin A, Flieger A, Ziegler U, Schmidt A, Hilbi H, Personnic N (2021)
EMBO Rep 22: e52972

Dictyostelium lacking the single atlastin homolog Sey1 shows aberrant ER architecture, proteolytic processes, and expansion of the Legionella-containing vacuole.
Hüsler D, Steiner B, Welin A, Striednig B, Swart AL, Molle V, Hilbi H, Letourneur F (2021)
Cell Microbiol 23: e13318

Zn2+ intoxication of Mycobacterium marinum during Dictyostelium discoideum infection is counteracted by induction of the pathogen Zn2+ exporter CtpC.
Hanna N, Koliwer-Brandl H, Lefrançois LH, Kalinina V, Cardenal-Muñoz E, Appiah J, Leuba F, Gueho A, Hilbi H, Soldati T, Barisch C (2021)
mBio 12: e01313-20

Quorum sensing controls persistence, resuscitation and virulence of Legionella subpopulations in biofilms.
Personnic N, Striednig B, Hilbi, H (2021)
ISME J 15: 196-210

Divergent evolution of Legionella RCC1 repeat effectors defines the range of Ran GTPase cycle targets.
Swart AL, Steiner, B, Schütz S, Gomez-Valero L, Hannemann M, Janning P, Irminger M, Rothmeier E, Buchrieser C, Itzen A, Panse VG, Hilbi H (2020)
mBio 11: e00405-20

The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization.
Hochstrasser R, Hutter CAJ, Arnold FA, Bärlocher K, Seeger MA, Hilbi H (2020)
Mol Microbiol 113: 1070-1084

Mycobacterium marinum produces distinct mycobactin and carboxymycobactin siderophores to promote growth in broth and phagocytes.
Knobloch P, Koliwer-Brandl H, Arnold FM, Hanna N, Gonda I, Adenau S, Personnic N, Barisch C, Seeger MA, Soldati T, Hilbi H (2020)
Cell Microbiol 22: e13163

Legionella quorum sensing meets cyclic-di-GMP signaling.
Hochstrasser R, Hilbi H. (2020)
Curr Opin Microbiol 55: 9-16

Phosphoinositides and the fate of Legionella in phagocytes.
Swart AL, Hilbi H (2020)
Front Immunol 11: 25

Evolution and function of bacterial RCC1 repeat effectors.
Swart AL, Gomez-Valero L, Buchrieser C, Hilbi H (2020)
Cell Microbiol 22: e13246

Quorum sensing modulates the formation of virulent Legionella persisters within infected cells.
Personnic N, Striednig B, Lezan E, Manske C, Welin A, Schmidt A, Hilbi H (2019)
Nat Commun 10: 5216

PIKfyve/Fab1 is required for efficient V-ATPase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.
Buckley CM, Heath V, Guého A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove S, Michel RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS (2019)
PLoS Pathog 15: e1007551

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.
Hilbi H, Kortholt A (2019)
Small GTPases 10: 336-342

The pleiotropic Legionella transcription factor LvbR links the Lqs and c-di-GMP regulatory networks to control biofilm architecture and virulence.
Hochstrasser R, Kessler A, Sahr T, Simon S, Schell U, Gomez-Valero L, Buchrieser C, Hilbi H (2019)
Environ Microbiol 21: 1035-1053

Distinct Mycobacterium marinum lipid phosphatases determine pathogen vacuole phosphoinositide pattern, phagosome maturation and escape to the cytosol.
Koliwer-Brandl H, Knobloch P, Barisch C, Welin A, Soldati T, Hilbi H (2019)
Cell Microbiol 21: e13008

Legionella-containing vacuoles capture PtdIns(4)P-rich vesicles derived from the Golgi apparatus.
Weber S, Steiner B, Welin A, Hilbi H (2018)
MBio 9: e02420-18

The large GTPase atlastin controls ER remodeling around a pathogen vacuole.
Steiner B, Weber S, Kaech A, Ziegler U, Hilbi H (2018)
Commun Integr Biol 11: 1-5

Quantitative imaging flow cytometry of Legionella-infected Dictyostelium reveals the impact of retrograde trafficking on pathogen vacuole composition.
Welin A, Weber S, Hilbi H (2018)
Appl Environ Microbiol 84: e00158

Acanthamoeba and Dictyostelium as host models for Legionella infection.
Swart AL, Harrison CF, Eichinger L, Steinert M, Hilbi H (2018)
Front Cell Infect Microbiol 8: 61

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
Bärlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA, Hilbi H (2017)
Nat Commun 8: 1543

Formation of the Legionella replicative compartment at the crossroads of retrograde trafficking.
Bärlocher K, Welin A, Hilbi H (2017)
Front Cell Infect Microbiol 7: 482

Legionella quorum sensing and its role in pathogen-host interactions.
Personnic N, Striednig B, Hilbi H (2017)
Curr Opin Microbiol 41: 29-35

ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila.
Steiner B, Swart AL, Welin A, Weber S, Personnic N, Kaech A, Freyre C, Ziegler U, Klemm RW, Hilbi H (2017)
EMBO Rep 18: 1817-1836

Legionella pneumophila modulates mitochondrial dynamics to trigger metabolic repurposing of infected macrophages.
Escoll P, Song OR, Viana F, Steiner B, Lagache T, Olivo-Marin JC, Impens F, Brodin P, Hilbi H, Buchrieser C (2017)
Cell Host Microbe 22: 302-316

Formation of the Legionella-containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics. 
Steiner B, Weber S, Hilbi H (2017)
Int J Med Microbiol 308: 49-57

Comparative proteomics of purified pathogen vacuoles correlates intracellular replication of Legionella pneumophila with the small GTPase Rap1.
Schmölders J, Manske C, Otto A, Hoffmann C, Steiner B, Welin A, Becher D, Hilbi H (2017)
Mol Cell Proteomics 16: 622-641

Intra-species and inter-kingdom signaling of Legionella pneumophila.
Hochstrasser R, Hilbi H (2017)
Front Microbiol 8: 79

Subversion of retrograde trafficking by translocated pathogen effectors.
Personnic N, Bärlocher K, Finsel I, Hilbi H (2016)
Trends Microbiol 24: 450-462

The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signaling and gene expression of Legionella pneumophila.
Schell U, Simon S, Sahr T, Hager D, Albers MF, Kessler A, Fahrnbauer F, Trauner D, Hedberg C, Buchrieser C, Hilbi H (2016)
Mol Microbiol 99: 778-793

Pathway analysis using 13C-glycerol and other carbon tracers reveals bipartite metabolism of Legionella pneumophila.
Häuslein I, Manske C, Goebel W, Eisenreich W, Hilbi H (2016)
Mol Microbiol 100: 229-246

Amoebae-based screening reveals a novel family of compounds restricting intracellular Legionella.
Harrison CF, Chiriano G, Finsel I, Manske C, Hoffmann C, Steiner B, Kranjc A, Pattey-Vuadens O, Kicka S, Trofimov V, Ouertatani-Sakouhi H, Soldati T, Scapozza L, Hilbi H (2015)
ACS Infect Dis 1: 327-338

Inter-kingdom signaling by the Legionella quorum sensing molecule LAI-1 inhibits cell migration through an IQGAP1/CDC42/ARHGEF9-dependent pathway.
Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C, Hilbi H (2015)
PLoS Pathog 11: e1005307

Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones.
Finsel I, Hilbi H (2015)
Cell Microbiol 17: 935-950

A type IV-translocated Legionella cysteine phytase counteracts intracellular growth restriction by phytate.
Weber S, Stirnimann CU, Wieser M, Frey D, Meier R, Engelhardt S, Li X, Capitani G, Kammerer RA, Hilbi H (2014)
J Biol Chem 289: 34175-34188

Phosphorylation signaling through the Legionella quorum sensing histidine kinases LqsS and LqsT converges on the response regulator LqsR.
Schell U, Kessler A, Hilbi H (2014)
Mol Microbiol 92: 1039–1055

Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator.
Simon S, Wagner M, Rothmeier E, Müller-Taubenberger A, Hilbi H (2014)
Cell Microbiol 16: 977–992

Functional analysis of novel small GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages.
Hoffmann C, Finsel I, Otto A, Pfaffinger G, Rothmeier E, Hecker M, Becher D, Hilbi H (2014)
Cell Microbiol 16: 1034–1052

Live cell imaging of phosphoinositide dynamics and membrane architecture during Legionella infection.
Weber S, Wagner M, Hilbi, H. (2014)
mBio 5: e00839-13

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.
Rothmeier E, Pfaffinger G, Hoffmann C, Harrison CF, Grabmayr H, Repnik U, Hannemann M, Wölke S, Bausch A, Griffith G, Müller-Taubenberger A, Itzen A, Hilbi H (2013)
PLoS Pathog 9: e1003598

Phosphoinositides and the Legionella pathogen vacuole. In Curr. Top. Microbiol. Immunol., Molecular mechanisms in Legionella pathogenesis. Hilbi, H. (ed.), Wiley Press.
Haneburger I, Hilbi H (2013)
Curr Top Microbiol Immunol; pp. 155-173

The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication.
Finsel I, Ragaz C, Hoffmann C, Harrison CF, Weber S, van Rahden VA, Johannes L, Hilbi H (2013)
Cell Host Microbe 14: 38–50

The Legionella pneumophila orphan sensor kinase LqsT regulates competence and pathogen-host interactions as a component of the LAI-1 circuit.
Kessler A, Schell U, Sahr T, Tiaden A, Harrison CF, Buchrieser C, Hilbi H (2013)
Environ Microbiol 15: 646-662

Bacterial gene regulation by α-hydroxyketone signaling.
Tiaden A, Spirig T, Hilbi H (2010)
Trends Microbiol 18: 288-297

The autoinducer synthase LqsA and putative sensor kinase LqsS regulate phagocyte interactions, extracellular filaments and a genomic island of Legionella pneumophila.
Tiaden A, Spirig T, Sahr T, Wälti MA, Boucke K, Buchrieser C, Hilbi H (2010)
Environ Microbiol 12: 1243-1259

The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.
Weber SS, Ragaz C, Hilbi H (2009)
Cell Microbiol 11: 442-460

Rab1 guanine nucleotide exchange factor SidM is a major PtdIns(4)P-binding effector protein of Legionella pneumophila.
Brombacher E, Urwyler S, Ragaz C, Weber SS, Kami K, Overduin M, Hilbi H (2009)
J Biol Chem 284: 4846–4856

Proteome analysis of Legionella vacuoles purified by magnetic immuno-separation reveals secretory and endosomal GTPases.
Urwyler S, Nyfeler Y, Ragaz C, Lee H, Mueller LN, Aebersold R, Hilbi H (2009)
Traffic 10: 76-87

The Legionella pneumophila phosphoinositide-4-phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole.

Ragaz C, Pietsch H, Urwyler S, Tiaden A, Weber SS, Hilbi H (2008)
Cell Microbiol 10: 2416-2433

The Legionella autoinducer synthase LqsA produces an α-hydroxyketone signaling molecule.
Spirig T, Tiaden A, Kiefer P, Buchrieser C, Vorholt JA, Hilbi H (2008)
J Biol Chem 283: 18113-18123

The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA.

Tiaden A, Spirig T, Weber SS, Brüggemann H, Bosshard R, Buchrieser C, Hilbi H (2007)
Cell Microbiol 9: 2903-2920

Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole.
Weber SS, Ragaz C, Reus K, Nyfeler Y, Hilbi H (2006)
PLoS Pathog 2: e46