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Institut für Medizinische Mikrobiologie

Alisa Garaeva

Dr. Alisa Garaeva

  • Postdoctoral Research Assistant
Tel.
+41 44 634 27 99

Curriculum vitae

working experience
2016-2021 PhD student, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Membrane Enzymology, Groningen, the Netherlands (Prof. D.J. Slotboom, Prof. C. Paulino, Prof. A. Guskov)
2019 EMBO short-term fellowship, Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland (Prof. M.A. Seeger)
2010-2015 Specialist (BSci+MSci) in bioengineering and bioinformatics, Moscow State University, Moscow, Russia

2011-2016

 Student intern in Laboratory of Molecular Biology of the Gene, Belozersky Institute of Physico-Chemical Biology, Moscow, Russia

2013

 Summer school in bioinformatics, Department of Microbiology, Leiden University Medical Center, Leiden, the Netherlands

2008-2010

 Cyril and Methodius Lyceum, focus on Chemistry and Biology, Smolensk, Russia

Research interests

  • Iron transport in Mycobacteria
  • Structure and function of membrane transport proteins
  • Single particle cryo-EM

Publications

Cryo-EM structure of the human neutral amino acid transporter ASCT2.
Garaeva AA, Oostergetel GT, Gati C, Guskov A, Paulino C, Slotboom DJ (2018)
Nat Struct Mol Biol 25: 515-521

Elevator-type mechanisms of membrane transport.
Garaeva AA, Slotboom DJ (2020)
Biochem Soc Trans 48: 1227-1241

A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2.
Garaeva AA, Guskov A, Slotboom DJ, Paulino C (2019)
Nat Commun 10: 3427

PnuT uses a facilitated diffusion mechanism for thiamine uptake.
Jaehme M, Singh R, Garaeva AA, Duurkens RH, Slotboom DJ (2018)
J Gen Physiol 150: 41-50

Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.
Garaeva AA, Kovaleva IE, Chumakov PM, Evstafieva AG (2016)
Cell Cycle 15: 64-71

Intermedin/adrenomedullin 2 is a stress-inducible gene controlled by activating transcription factor 4.
Kovaleva IE, Garaeva AA, Chumakov PM, Evstafieva AG (2016)
Gene 590: 177-85

A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4.
Evstafieva AG, Garaeva AA, Khutornenko AA, Klepikova AV, Logacheva MD, Penin AA, Novakovsky GE, Kovaleva IE, Chumakov PM (2014)
Cell Death Dis 5: e1511