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Institut für Medizinische Mikrobiologie

Prof. Dr. Vikram Govind Panse

Prof. Dr. Vikram Govind Panse

  • Research Group Leader
+41 44 634 53 16


2020-present Associate Professor ad personam for Molecular Microbiology at the Faculties of Medicine (MeF) and Science (MNF)
2016 Full Professor and Directorship call at the Institute of Biochemistry, University of Innsbruck, Austria. (gratefully declined)
2010-2016 SNF and ERC Assistant Professor at the ETH Zürich and UZH
2007-2009 Independent Research Group Leader at the ETH Zürich
2001-2006 Post-doctoral work in Ed Hurt’s laboratory at the University of Heidelberg, Germany.
1998-1999 DAAD visiting graduate student at the TU Kaiserslautern, Germany
1995-2001 Doctoral thesis in Prof. Raghavan Varadarajan’s laboratory at the Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
1990-1995 B.Sc. and M.Sc. Chemistry at Pune University, India



2010 European Research Council (ERC) Starting Grant Award (as Consolidator)
2010 Swiss National Science Foundation Professorship
2000-2003 Human Frontier Science Program (HFSP) Long-term Post-doc Fellowship
1999 Journal of Cell Science Travelling Fellowship
1998 Wood-Whelan Research Fellowship, IUBMB
1995 Doctoral Fellowship from Council of Scientific and Industrial Research (CSIR), India


Reserach interests

  • Ribosome Assembly, Maturation and Quality Control
  • Targeted RNA degradation

Selected Publications

RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing.
Moursy A, Cléry A, Gerhardy S, Betz KM, Rao S, Mazur J, Campagne S, Beusch I, Duszczyk MM, Robinson MD, Panse VG, Allain FH (2023)
Nat Commun 14: 7166

Puf6 primes 60S pre-ribosome nuclear export at low temperature.
Gerhardy S, Oborská-Oplová M, Gillet L, Börner R, van Nues R, Leitner A, Michel E, Petkowski JJ, Granneman S, Sigel RKO, Aebersold R, Panse VG (2021)
Nat Commun 12: 4696

The GTPase Nog1 co-ordinates assembly, maturation and quality control of distant ribosomal functional centers.
Klingauf-Nerurkar P, Gillet LC, Portugal-Calisto D, Oplova M, Jäger M, Schubert OT, Pisano A, Peña C, Rao S, Altvater M, Chang Y, Aebersold R, Panse VG (2020)
Elife 9: e52474

Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.
Schütz S, Michel E, Damberger FF, Oplová M, Peña C, Leitner A, Aebersold R, Allain FH, Panse VG (2018)
Nat Commun 9: 3669

Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit.
Scaiola A, Peña C, Weisser M, Böhringer D, Leibundgut M, Klingauf-Nerurkar P, Gerhardy S, Panse VG, Ban N (2018)
EMBO J 37: e98499

Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation.
Peña C, Schütz S, Fischer U, Chang Y, Panse VG (2016)
Elife 5: e21755

Insertion of the biogenesis factor Rei1 probes the ribosome tunnel during 60S subunit maturation.
Greber BJ, Gerhardy S, Leitner A, Leibundgut M, Salem M, Boehringer D, Leulliot N, Aebersold R, Panse VG, Ban N (2016)
Cell 164: 91-102

A non-canonical mechanism for Crm1-export complex assembly.
Rothenbusch U, Schäuble N, Altvater M, Schütz S, Faza MB, Panse VG (2015)
Elife 10.7554/eLife.05745

A Ran-independent mechanism allows ribosomal protein nuclear import for ribosome assembly.
Schütz S, Rothenbusch U, Gerber M, Peña C, Altvater M, Caeser S, Nerurkar P, Schubert O, Schlenstedt G, Panse VG (2014)
eLife 3: e03473

Targeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear export.
Altvater M, Chang Y, Melnik A, Occhipinti L, Schütz S, Rothenbusch U, Picotti P, Panse VG (2012)
Mol Syst Biol 8: 628

Role of Mex67-Mtr2 in the nuclear export receptor for 40S pre-ribosomes.
Faza MB, Chang Y, Occhipinti L, Kemmler S, Panse VG (2012)
PLoS Genet 8: e1002915

Yvh1 is required for a late maturation step in the 60S biogenesis pathway.
Kemmler S, Occhinpinti L, Veisu M, Panse VG (2009)
J Cell Biol 186: 863-80

Sem1 is a functional component of the nuclear pore complex-associated mRNA export machinery.
Faza MB, Kemmler S, Jimeno S, González-Aguilera C, Aguilera A, Hurt E, Panse VG (2009)
J Cell Biol 184: 833-46