Selected Literature

Synthetic single domain antibodies for the conformational trapping of membrane proteins.
Zimmermann I, Egloff P, Hutter CA, Arnold FM, Stohler P, Bocquet N, Hug MN, Huber S, Siegrist M, Hetemann L, Gera J, Gmür S, Spies P, Gygax D, Geertsma ER, Dawson RJ, Seeger MA (2018)
Elife 7: e34317

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
Bärlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA, Hilbi H (2017)
Nat Commun 8: 1543

Split tasks of asymmetric nucleotide-binding sites in the heterodimeric ABC exporter EfrCD.
Hürlimann LM, Hohl M, Seeger MA (2017)
FEBS J: Epub ahead of print

Exploring conformational equilibria of a heterodimeric ABC transporter.
Timachi MH, Hutter CAJ, Hohl M, Assafa T, Böhm S, Mittal A, Seeger MA and Bordignon E (2017)
Elife 6: e20236

The heterodimeric ABC transporter EfrCD mediates multidrug efflux in Enterococcus faecalis.
Hürlimann LM, Corradi V, Hohl M, Bloemberg GV, Tieleman DP, Seeger MA (2016)
Antimicrob Agents Chemother: 60: 5400-5411

ABC Exporters from a Structural Perspective
Seeger MA, Bordignon E, Hohl M (2016)
Chapter ABC Transporters - 40 Years on, pp 65-84

A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.
Bukowska MA, Hohl M, Geertsma ER, Hürlimann LM, Grütter MG, and Seeger MA (2015)
Biochemistry 54: 3086–3099

Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
Hohl M, Hürlimann LM, Böhm S, Schöppe J, Grütter MG, Bordignon E, Seeger MA (2014)
Proc Natl Acad Sci U S A 111: 11025-11030

Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders.
Seeger MA, Mittal A, Velamakanni S, Hohl M, Schauer S, Salaa I, Grütter MG, van Veen HW (2012)
PLoS One 7: e37845

Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin.
Mittal A, Böhm S, Grütter MG, Bordignon E, Seeger MA (2012)
J Biol Chem 287: 20395-20406

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation.
Hohl M, Briand M, Grütter MG, Seeger MA (2012)
Nat Struct Mol Biol 19: 395-402

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Eicher T, Cha HJ, Seeger MA, Brandstatter L, El-Delik J, Bohnert JA, Kern WV, Verrey F, Grütter MG, Diederichs K, Pos KM (2012)
Proc Natl Acad Sci USA 109: 5687-5692

Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling.
Seeger MA, von Ballmoos C, Verrey F, Pos KM (2009)
Biochemistry 48: 5801-5812

Molecular basis of multidrug transport by ABC transporters.
Seeger MA and van Veen HW (2009)
Biochim Biophys Acta 1794: 725-737

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions.
Barrera NP, Isaacson SC, Zhou M, Bavro VN, Welch A, Schaedler TA, Seeger MA, Miguel RN, Korkhov VM, van Veen HW, Venter H, Walmsley AR, Tate CG, Robinson CV (2009)
Nat Methods 6: 585-587

Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.
Seeger MA, von Ballmoos C, Eicher T, Brandstatter L, Verrey F, Diederichs K, Pos KM (2008)
Nat Struct Mol Biol 15: 199-205

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.
Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM (2006)
Science 313: 1295-1298