Selected Literature

Synthesis and antiribossomal, activities of 4’-0-, 6’-0-,4’’,6’’-0-derivatives in the kanamycin series reveal differing target selectivity patterns between the 4.5- and 4.6- series of disubstituted 2-deoxystreptamine classes of aminoglycoside antibiotics.
Kato T, Yang G, Youjin T, Juskeviciene R, Perez-Fernandez D, Shinde HM, Salian S, Bernet B, Vasella A, Böttger EC, Crich D (2015)
ACS Infect Dis 1: 479-486

4’-O-substitutions determine selectivity of aminoglycoside antibiotics.
Perez-Fernandez D,  Shcherbakov D,  Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Pathak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC (2014)
Nature Commun 5: 3112

Importance of the 6'-hydroxy group and its configuration for apramycin activity.
Mandhapati AR, Shcherbakov D, Duscha S, Vasella A, Böttger EC, Crich D (2014)
Chem Med Chem 9: 2074-2083

In-vivo efficacy of apramycin in murine infection models.
Meyer M, Freihofer P, Scherman M, Teague J, Lenaerts A, Böttger EC (2014)
Antimicrob Agents Chemother 58: 6938-6941

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.
Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, and Böttger EC (2012)
Proc Natl Acad Sci USA 109: 10984-10989

Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma.
Hobbie SN, Kaiser M, Schmidt S, Shcherbakov D, Janusic T, Brun R, and Böttger EC (2011)
PLoS Negl Trop Dis 5: e1161

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.
Hobbie SN, Akshay S, Kalapala SK, Bruell CM, Sherbakov D, and Böttger EC (2008)
Proc Natl Acad Sci USA 105: 20888-20893

Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria.
Hobbie SN, Kalapala SK, Akshay S, Bruell C, Dabow S, Vasella A, Sander P, and Böttger EC (2007)
Nucleic Acids Res 35: 6086-6093

Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A-site of 16S rRNA.
Hobbie SN, Pfister P, Bruell C, Sander P, François B, Westhof E, and Böttger EC (2006)
Antimicrob Agents Chemother 50: 1489-1496

A genetic model to investigate drug-target interactions at the ribosomal decoding site.
Hobbie SN, Bruell C, Kalapala S, Akshay S, Schmidt S, Pfister P, and Böttger EC (2006)
Biochimie 88: 1033-1043

Mutagenesis of 16S rRNA C1409-G1491 base pair differentiates between 6'OH and 6'NH3+ aminoglycosides.
Pfister P, Hobbie S, Brüll C, Corti N, Vasella A, Westhof E, and Böttger EC (2005)
J Mol Biol 346: 467-475

Analysis of the contribution of individual substituents in 4,6 aminoglycoside-ribosome interaction.
Hobbie SN, Pfister P, Bruell C, Westhof E, and Böttger EC (2005)
Antimicrob Agents Chemother 49: 5112-5118