Selected Literature


  1. Diagnostic molecular mycobacteriology in regions with low tuberculosis endemicity: combining real-time PCR assays for detection of multiple mycobacterial pathogens with line probe assays for identification of resistance mutations.
    Deggim-Messmer V, Bloemberg GV, Ritter C, Voit A, Hömke R, Keller PM, Böttger EC (2016)
    EBioMedicine 9: 228-237
  2. Relative contribution of biological variation and technical variables to zone diameter variations of disc diffusion susceptibility testing.
    Hombach M, Ochoa C, Maurer FP, Pfiffner T, Böttger EC, Furrer R (2016)
    J Antimicrob Chemother 71: 141-151
  3. Evaluation of the Bruker MALDI Biotyper for the identification of fastidious Gram-negative rods.
    Schulthess B, Bloemberg GV, Zbinden A, Mouttet F, Zbinden, R, Böttger EC, Hombach M (2016)
    J Clin Microbiol 54: 543-548
  4. Performance of Copan WASP for Routine Urine Microbiology.
    Quiblier C*, Jetter M*, Rominski M, Mouttet F, Böttger EC, Keller PM*, Hombach M* (2016)
    J Clin Microbiol 54: 585-592


  1. The Resistant-Population Cutoff (RCOFF): a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations.
    Valsesia G, Hombach M, Maurer FP, Courvalin P, Roos M, Böttger EC (2015)
    J Clin Microbiol 53: 1806-1811
  2. Prolonged outbreak of Mycobacterium chimaera infection after open chest heart surgery.
    Sax H, Bloemberg G, Hasse B, Sommerstein R, Kohler P, Achermann Y, Rössle M, Falk V, Kuster SP, Böttger EC, Weber R (2015)
    Clin Infect Dis 61: 67-75
  3. Determination of MIC distribution and epidemiological cut-off values for bedaquiline and delamanid in Mycobacterium tuberculosis using MGIT 960/ TB eXiST.
    Keller P, Hömke R, Ritter C, Valsesia G, Bloemberg GV, Böttger EC (2015)
    Antimicrob Agents Chemother 59: 4352-4355
  4. Health-care associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery.
    Kohler P, Kuster SP, Bloemberg GV, Schulthess B, Frank M, Tanner FC, Rössle M, Böni C, Falk V, Wilhelm MJ, Sommerstein R, Achermann Y, ten Oever J, Debast SB, Wolfhagen MJHM, Brandon Bravo Bruinsma GJ, Vos MC, Bogers A, Serr A, Beyersdorf F, Sax H, Böttger EC, Weber R, van Ingen J, Wagner D, Hasse B (2015)
    Eur Heart J 36: 2745-2753
  5. Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis.
    Bloemberg GV, Keller P, Stucki D, Trauner A, Borrell S, Latshang T, Coscolla N, Rothe T, Hömke R, Ritter C, Feldmann J, Schulthess B, Gagneux S, Böttger EC (2015)
    N Engl J Med 373: 1986-1988
  6. Standardization of operator-dependent variables affecting precision and accuracy of the disk diffusion method for antibiotic susceptibility testing.
    Hombach M, Maurer FP, Pfiffner T, Böttger EC, Furrer R (2015)
    J Clin Microbiol 53: 3864-3869
  7. A statistical approach for determination of disk diffusion-based cutoff values for systematic characterization of wild-type and non-wild-type bacterial populations in antimicrobial susceptibility testing.
    Valsesia G, Roos M, Böttger EC, Hombach M (2015)
    J Clin Microbiol 53: 1812-1822
  8. Revisiting susceptibility testing in multidrug resistant tuberculosis by a standardized quantitative phenotypic assessment in a European multicenter study.
    Cambau E, Viveiros M, Machado D, Raskine L, Ritter C, Tortoli E, Mattys V, Hoffner S, Richter E, Perez-del-Molino L, Cirillo D, van Soolingen D, Böttger EC (2015)
    J Antimicrob Chemother 70: 686-696
  9. Evaluation of carbapenemase screening and confirmation tests in Enterobacteriaceae and development of a practical diagnostic algorithm.
    Maurer F, Castelberg C, Quiblier C, Bloemberg G, Hombach M (2015)
    J Clin Microbiol 53: 95-104
  10. A mutation associated with clofazimine and bedaquiline cross-resistance in MDRTB following bedaquiline treatment.
    Somoskovi A, Bruderer V,Hömke R, Bloemberg GV, Böttger EC (2015)
    Eur Respir J 45: 554-557
  11. Clonality and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus at the University Hospital Zurich, Switzerland between 2012 and 2014.
    Seidl K, Leimer N, Marques MP, Furrer A, Holzmann-Bürgel A, Senn G, Zbinden R, Zinkernagel AS (2015)
    Ann Clin Microb Antimicro 14: 1-7
  12. Aggregatibacter, Capnocytophaga, Eikenella, Kingella, Pasteurella, and other fastidious or rarely encountered Gram-negative rods.
    R. Zbinden (2015)
    In Manual of Clinical Microbiology 11th Edition, 652-666
    Jorgensen JH, Pfaller MA, Carroll KC, Funke G, Landry ML, Richter SS, Warnock DW (eds) ASM press, Washington DC, USA


  1. Evaluation of the AID ESBL line probe assay for rapid detection of extended spectrum β-lactamases (ESBL) and KPC carbapenamase genes in Enterobacteriaceae.
    Bloemberg GV, Polsfuss S, Meyer V, Böttger EC, Hombach M (2014)
    J Antimicrob Chemother 69: 85-90
  2. Evaluation of the AID TB Resistance line probe assay for rapid detection of genetic alterations associated with Mycobacterium tuberculosis drug resistance.
    Ritter C, Lucke K, Sirgel FA, Warren RW, van Helden PD, Böttger EC, Bloemberg GV (2014)
    J Clin Microbiol 52: 940-946
  3. Transmission of multidrug-resistant tuberculosis in low-incidence setting, Switzerland, 2006 to 2012.
    Somoskovi A, Helbling P, Deggim V, Hömke R, Ritter C, Böttger EC (2014)
    Euro Surveill 19(11)
  4. Evaluation of the Bruker MALDI Biotyper for identification of Gram-positive rods - development of a diagnostic algorithm for the clinical laboratory.
    Schulthess B, Bloemberg G, Zbinden R, Böttger E, Hombach M (2014)
    J Clin Microbiol 52: 1089-1097
  5. Lack of antimicrobial bactericidal activity in Mycobacterium abscessus.
    Maurer F, Bruderer V, Ritter C, Castelberg C, Bloemberg GV, Böttger EC (2014)
    Antimicrob Agents Chemother 58: 3828-3836
  6. Validation of antibiotic susceptibility testing guidelines in a routine clinical microbiology laboratory exemplifies general key challenges in setting clinical breakpoints.
    Hombach M, Courvalin P, Böttger EC (2014)
    Antimicrob Agents Chemother 58: 3921-3926
  7. Use of the Bruker MALDI Biotyper for the identification of molds in the clinical mycology laboratory.
    Schulthess B, Ledermann R, Mouttet F, Zbinden A, Bloemberg GV, Böttger EC, Hombach M (2014)
    J Clin Microbiol 52: 2797-2803
  8. Candida species distribution and antifungal susceptibility testing according to EUCAST and new vs. old CLSI clinical breakpoints: a six-year prospective candidemia survey from the Fungal Infection Network of Switzerland (FUNGINOS).
    Orasch C, Marchetti O, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Rossi M, Pfyffer G, Ruef C, Fehr J, Zbinden R, Calandra T, Bille J; The Fungal Infection Network of Switzerland (FUNGINOS) (2014)
    Clin Microbiol Infect 20: 698-705
  9. Postsurgical wound infections due to rapidly growing myciobacteria in Swiss medical tourists following cosmetic surgery in Latin America between 2012 and 2014.
    Maurer FP, Castelberg C, von Braun A, Wolfensberger A, Bloemberg GV, Böttger EC, Somoskovi A (2014)
    Euro Surveill 19: 37
  10. Integrating forecast probabilities in antibiograms - a way to guide antimicrobial prescriptions more reliably?
    Maurer FP, Courvalin P, Böttger EC, Hombach M (2014)
    J Clin Microbiol 52: 3674-3684


  1. Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera.
    Achermann Y, Rössle M, Hoffmann M, Deggim V, Kuster S, Zimmermann DR, Bloemberg GV, Hombach M, Hasse B (2013)
    J Clin Microbiol 51: 1769-1773
  2. Consequences of revised CLSI and EUCAST guidelines for antibiotic susceptibility patterns of ESBL- and AmpC β-lactamase-producing clinical Enterobacteriaceae isolates.
    Hombach M, Mouttet B, Bloemberg GV (2013)
    J Antimicrob Chemother 68: 2092-2098
  3. Close geographic association of human neoehrlichiosis and tick populations carrying Candidatus Neoehrlichia mikurensis in eastern Switzerland.
    Maurer FP, Keller PM, Beuret C, Joha C, Achermann Y, Gubler J, Bircher D, Karrer U, Fehr J, Zimmerli L, Bloemberg GV (2013)
    J Clin Microbiol 51: 169-176
  4. Identification of Gram-positive cocci using MALDI-TOF MS: comparison of different preparation methods and implementation of a practical algorithm for routine diagnostics.
    Schulthess B, Brodner K, Bloemberg G, Zbinden R, Böttger E, Hombach M (2013)
    J Clin Microbiol 51: 1834-1840
  5. Evaluation of COBAS TaqMan MTB for direct detection of Mycobacterium tuberculosis complex in comparison with the COBAS Amplicor MTB.
    Bloemberg GV, Voit A, Ritter C, Deggim V, Böttger EC (2013)
    J Clin Microbiol 51: 2112-2117
  6. Integrating the Xpert MTB/RIF assay in a diagnostic work flow for rapid detection of Mycobacterium tuberculosis in a low prevalence area.
    Deggim V, Somoskövi A, Voit A, Böttger EC, Bloemberg GV (2013)
    J Clin Microbiol 51: 2396-2399
  7. Influence of clinical breakpoint changes from CLSI 2009 to EUCAST 2011 AST guidelines on multi drug resistance rates of Gram-negative rods.
    Hombach M, Wolfensberger A, Kuster SP, Böttger EC (2013)
    J Clin Microbiol 51: 2385-2387
  8. The critical influence of the intermediate category on interpretation errors in revised EUCAST and CLSI antimicrobial susceptibility testing guidelines.
    Hombach M, Böttger EC, Roos M (2013)
    Clin Microbiol Infect 19: E59-71
  9. Standardisation of disk diffusion results for antibiotic susceptibility testing using the sirscan automated zone reader.
    Hombach M, Zbinden R, Böttger EC (2013)
    BMC Microbiol 13: 225


  1. Comparison of EUCAST and CLSI screening parameters for the detection of extended spectrum beta-lactamase (ESBL) production in clinical Enterobacteriaceae isolates.
    Polsfuss S, Bloemberg GV, Giger J, Meyer V, Hombach M (2012)
    J Antimicrob Chemother 67: 159-166
  2. Effects of clinical breakpoint changes in CLSI guidelines 2010/2011 and EUCAST guidelines 2011 on antibiotic susceptibility test reporting of Gram-negative bacilli.
    Hombach M, Bloemberg GV, Böttger EC (2012)
    J Antimicrob Chemother 67: 622-632
  3. Evaluation of a diagnostic flow-chart for detection and confirmation of extended spectrum beta-lactamases (ESBL) in Enterobacteriaceae.
    Polsfuss S, Bloemberg GV, Giger J, Meyer V, Böttger EC, Hombach M (2012)
    Clin Microbiol Infect 18: 1194-1204
  4. Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41) methylase.
    Maurer F, Rüegger V, Ritter C, Bloemberg GV, Böttger EC (2012)
    J Antimicrob Chemother 67: 2606-2611
  5. Streptococcus tigurinus sp. nov., isolated from blood of patients with endocarditis, meningitis and spondylodiscitis.
    Zbinden A, Müller NJ, Tarr PE, Spröer C, Keller PM, Bloemberg GV (2012)
    Int J Syst Evol Microbiol 62: 2941-2945
  6. Streptococcus tigurinus, a novel member of the Streptococcus mitis group, causes invasive infections..
    Zbinden A, Mueller NJ, Tarr PE, Eich G, Schulthess B, Bahlmann AS, Keller PM, Bloemberg GV (2012)
    J Clin Microbiol 50: 2969-2973