Publikationen/Publications (selected)


  1. Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multi-centre cohort study.
    Zürcher K, Ballif M, Fenner L, Borrell S, Keller PM, Gnokoro J, Marcy O, Yotebieng M, Diero L, Carter EJ, Rockwood N, Wilkinson RJ, Cox H, Ezati N, Abimiku AG, Collantes J, Avihingsanon A, Kawkitinarong K, Reinhard M, Hömke R, Huebner R, Gagneux S, Böttger EC, Egger M (2018)
    Lancet Infect Dis: Epub ahead of print
  2. Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes.
    Panasenko OO, Somasekharan SP, Villanyi Z, Zagatti M, Bezrukov F, Rashpa R, Cornut J, Iqbal J, Longis M, Carl SH, Peña C, Panse VG, Collart MA (2019)
    Nat Struct Mol Biol: Epub ahead of print
  3. Whole genome sequencing for drug resistance profile prediction in Mycobacterium tuberculosis
    Gygli S, Keller P, Ballif M, Blöchliger N, Hömke R, Reinhard M, Loiseau C, Ritter C, Sander P, Borrell S, Collantes J, Avihingsanon A, Gnokoro J, Yotebieng M, Egger M, Gagneux S, Böttger EC (2019)
    Antimicrob Agents Chemother: accepted
  4. In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.
    Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, Rominski A, Crich D, Böttger EC, Walsh TR, Hughes D, Hobbie SN (2019)
    J Antimicrob Chemother: Epub ahead of print
  5. The pleiotropic Legionella transcription factor LvbR links the Lqs and c-di-GMP regulatory networks to control biofilm architecture and virulence.
    Hochstrasser R, Kessler A, Sahr T, Simon S, Schell U, Gomez-Valero L, Buchrieser C, Hilbi H (2019)
    Environ Microbiol: Epub ahead of print
  6. Distinct Mycobacterium marinum phosphatases determine pathogen vacuole phosphoinositide pattern, phagosome maturation and escape to the cytosol.
    Koliwer-Brandl H, Knobloch P, Barisch C, Welin A, Hanna N, Soldati T, Hilbi H (2019)
    Cell Microbiol: Epub ahead of print
  7. PIKfyve/Fab1 is required for efficient V-ATPase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.
    Buckley CM, Heath V, Guého A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove  S, Michel RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS (2019)
    PloS Pathog: accepted
  8. Genetic determinants and prediction of antibiotic resistance phenotypes in Helicobacter pylori.
    Lauener FN, Imkamp F, Lehours P, Buissonnière A, Benejat L, Zbinden R, Keller PM, Wagner K (2019)
    Journal of Clinical Medicine 8: 53 (PDF, 731 KB)
  9. Discovery and characterization of Mycobacterium basiliense sp nov, a nontuberculous mycobacterium isolated from human lungs.
    Seth-Smith HM, Imkamp F, Tagini F, Cuenod A, Hoemke R, Tschacher JK, Grendelmeier P, Baettig V, Erb S, Reinhard M, Ruettimann G, Borrell S, Gagneux S, Casanova C, Droz S, Osthoff M, Tamm M, Nübel U, Greub G, Keller PM, Egli A (2019)
    Frontiers in Microbiolgy 9: 3184

    Book Chapters
  10. Preface
    Buchrieser C., Hilbi H (2019)
    In Meth. Mol. Biol. 1921, Legionella: methods and protocols, 2nd edition. Buchrieser, C. & Hilbi, H. (eds.), Springer Press; pp. v-xviii
  11. Migration of Acanthamoeba castellanii through Legionella Biofilms.
    Hochstrasser R, Hilbi H (2019)
    In Meth. Mol. Biol. 1921, Legionella: methods and protocols, 2nd edition. Buchrieser, C. & Hilbi, H. (eds.), Springer Press; pp. 79-89
  12. Quantitative imaging flow cytometry of Legionella-containing vacuoles in dually fluorescence-labelled Dictyostelium.
    Welin A, Weber S, Hilbi H (2019)
    In Meth. Mol. Biol. 1921, Legionella: methods and protocols; 2nd edition. Buchrieser, C. & Hilbi, H. (eds.), Springer Press; pp. 161-177
  13. Single cell analysis of Legionella and Legionella-infected Acanthamoeba by agarose embedment.
    Personnic N, Striednig B, Hilbi H (2019)
    In Meth. Mol. Biol. 1921, Legionella: methods and protocols; 2nd edition. Buchrieser, C. & Hilbi, H. (eds.), Springer Press; pp. 191-204
  14. Perturbation of Legionella infection by RNA interference.
    Steiner B, Swart AL, Hilbi H (2019)
    In Meth. Mol. Biol. 1921, Legionella: methods and protocols; 2nd edition. Buchrieser, C. & Hilbi, H. (eds.), Springer Press; pp. 191-204.


  1. Ribosome levels selectively regulate translation and lineage commitment to human hematopoiesis.
    Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP, Engreitz JM, Schütz S, Lian J, Gripp KW, Weinberg OK, Pinkus GS, Gehrke L, Regev A, Lander ES, Gazda HT, Lee Wy, Panse VG, Carr SA, Sankaran VG (2018)
    Cell 173: 90-103
  2. A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.
    Walker TM, Merker M, Knoblauch AM, Helbling P, Schoch OD, van der Werf MJ, Kranzer K, Fiebig L, Kröger S, Haas W, Hoffmann H, Indra A, Egli A, Cirillo DM, Robert J, Rogers TR, Groenheit R, Mengshoel AT, Mathys V, Haanperä M, Soolingen DV, Niemann S, Böttger EC, Keller PM; MDR-TB Cluster Consortium (2018)
    Lancet Infect Dis 18: 431-440
  3. Correction to: Catheter retention as a consequence rather than a cause of unfavorable outcome in candidemia.
    Damonti L, Erard V, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Imhof A, Zbinden R, Fehr J, Boggian K, Bruderer T, Flückiger U, Frei R, Orasch C, Conen A, Khanna N, Bregenzer T, Bille J, Lamoth F, Marchetti O, Bochud PY; Fungal Infection Network of Switzerland (FUNGINOS) (2018)
    Intensive Care Med 44: 405-407
  4. Atomistic Mechanism of Large-Scale Conformational Transition in a Heterodimeric ABC Exporter.
    Göddeke H, Timachi MH, Hutter CAJ, Galazzo L, Seeger MA, Karttunen M, Bordignon E, Schäfer LV (2018)
    J Am Chem Soc 140: 4543-4551
  5. Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.
    Schütz S, Michel E, Damberger FF, Oplová M, Peña C, Leitner A, Aebersold R, Allain FH, Panse VG (2018)
    Nat Commun 9: 3669
  6. Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement.
    van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ Jr, Winthrop KL, Wagner D; for NTM-NET (2018)
    Eur Respir J 51: 1800170
  7. Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit.
    Scaiola A, Peña C, Weisser M, Böhringer D, Leibundgut M, Klingauf-Nerurkar P, Gerhardy S, Panse VG, Ban N (2018)
    EMBO J 37: e98499
  8. Association of Cutibacterium avidum Colonization in the Groin With Obesity: A Potential Risk Factor for Hip Periprosthetic Joint Infection.
    Böni L, Kuster SP, Bartik B, Zbinden R, Zingg PO, Achermann Y (2018)
    Clin Infect Dis 67: 1878-1882
  9. Propionibacterium avidum – a virulent pathogen causing hip periprosthetic joint infection.
    Achermann Y, Liu J, Zbinden R, Zingg PO, Anagnostopoulos A, Barnard E, Sutter R, Li H, McDowell A, Zinkernagel AS (2018)
    Clin Infect Dis 66: 54-63
  10. Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.
    Akbergenov R, Duscha S, Fritz A-K, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC (2018)
    EMBO Rep 19: e46193
  11. The Mycobacterial LexA/RecA-Independent DNA Damage Response Is Controlled by PafBC and the Pup-Proteasome System.
    Müller AU, Imkamp F, Weber-Ban E (2018)
    Cell Reports 23: 3551-3564
  12. Multiplex PCR on the Bronchoalveolar Lavage Fluid of Immunocompromised Patients.
    Affolter K, Schumann DM, Tamm M, Jahn K, Siebeneichler A, Junker L, Wagner K, Keller PM, Frei R, Stolz D (2018)
    Chest 154: 722-725
  13. Synthetic single domain antibodies for the conformational trapping of membrane proteins.
    Zimmermann I, Egloff P, Hutter CA, Arnold FM, Stohler P, Bocquet N, Hug MN, Huber S, Siegrist M, Hetemann L, Gera J, Gmür S, Spies P, Gygax D, Geertsma ER, Dawson RJ, Seeger MA (2018)
    Elife 7: e34317
  14. Aortic Endograft Infection with Mycobacterium chimaera and Granulicatella adiacens, Switzerland, 2014.
    Plate A, Kohl TA, Keller PM, Majer S, Fulchini R, Strahm C, Medugno C, Rancic Z, Husmann L, Sax H, Niemann S, Hasse B (2018)
    Emerg Infect Dis 24: 1700-1704
  15. Global health estimate of invasive Mycobacterium chimaera infections associated with heater-cooler devices in cardiac surgery.
    Sommerstein R, Hasse B, Marschall J, Sax H, Genoni M, Schlegel M, Widmer AF; Swiss Chimaera Taskforce (Consiglio J, Erny S, Gardiol C, Häussler A, Keller PM, Koch D, Masserey V, Moreno R, Schulthess B, Wälti M) (2018)
    Emerg Infect Dis 24: 576-578
  16. Legionella-containing vacuoles capture PtdIns(4)P-rich vesicles derived from the Golgi apparatus.
    Weber S, Steiner B, Welin A, Hilbi H (2018)
    MBio 9: e02420-18
  17. Inflammatory disorders mimicking periprosthetic joint infections may result in false-positive α-defensin.
    Plate A, Stadler L, Sutter R, Anagnostopoulos A, Frustaci D, Zbinden R, Fucentese SF, Zinkernagel AS, Zingg PO, Achermann Y (2018)
    Clin Microbiol Infect 24: 1212.e1-1212.e6
  18. Evaluation of the Lightmix® Mycoplasma macrolide assay for the detection of macrolide resistant Mycoplasma pneumoniae in pneumonia patients.
    Wagner K, Imkamp F, Pires V, Keller PM (2018)
    Clin Microbiol Infect: Epub ahead of print
  19. Rapid disk diffusion antibiotic susceptibility testing for Pseudomonas aeruginosa, Acinetobacter baumanii and Enterococcus.
    Hombach M, Jetter M, Keller PM, Blöchliger N, Kolesnik-Goldmann N, Böttger EC (2018)
    J Antimicrob Chemother 73: 385-391
  20. Combining forecast probabilities with graphical visualization for improved reporting of antimicrobial susceptibility testing.
    Mancini S, Marchesi M, Blöchliger N, Schmid M, Courvalin P, Keller P, Böttger EC (2018)
    J Antimicrob Chemother 73: 2266-2268
  21. Fluconazole non-susceptible breakthrough candidemia after prolonged low-dose prophylaxis: a prospective FUNGINOS study.
    Orasch C, Mertz D, Garbino J, van Delden C, Emonet S, Schrenzel J, Zimmerli S, Damonti L, Mühlethaler K, Imhof A, Ruef C, Fehr J, Zbinden R, Boggian K, Bruderer T, Flückiger U, Conen A, Khanna N, Frei R, Bregenzer T, Lamoth F, Erard V, Bochud PY, Calandra T, Bille J, Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS) (2018)
    J Infect 76: 489-495
  22. Effects of the 1- N-(4-amino-2 S-hydroxybutyryl) and 6'- N-(2-hydroxyethyl) substituents on ribosomal selectivity, cochleotoxicity, and antibacterial activity in the sisomicin class of aminoglycoside antibiotics.
    Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D (2018)
    ACS Infect Dis 4: 1114-1120
  23. Molecular mechanisms of intrinsic streptomycin resistance in Mycobacterium abscessus.
    Dal Molin M, Gut M, Rominski A, Haldimann K, Becker K, Sander P (2018)
    Antimicrob Agents Chemother 62: e01427-17
  24. A uniform cloning platform for mycobacterial genetics and protein production.
    Arnold FM, Hohl M, Remm S, Koliwer-Brandl H, Adenau S, Chusri S, Sander P, Hilbi H, Seeger MA (2018)
    Sci Rep 8: 9539
  25. Molecular detection of fungal pathogens in clinical specimens by 18S rDNA high-throughput screening in comparison to ITS PCR and culture.
    Wagner K, Springer B, Pires VP, Keller PM (2018)
    Sci Rep 8: 6964
  26. Corynebacterium species rarely cause orthopedic infections.
    Kalt F, Schulthess B, Sidler F, Herren S, Fucentese SF, Zingg PO, Berli M, Zinkernagel AS, Zbinden R, Achermann Y (2018)
    J Clin Microbiol 56: e01200-18
  27. Whole-Genome Sequencing of Aggregatibacter Species Isolated from Human Clinical Specimens and Description of Aggregatibacter kilianii sp. nov.
    Murra M, Lützen L, Barut A, Zbinden R, Lund M, Villesen P, Nørskov-Lauritsen N (2018)
    J Clin Microbiol 56: e00053-18
  28. Pathogen identification by multiplex Lightmix® RT-PCR in patients with meningitis and culture-negative cerebrospinal fluid.
    Wagner K, Springer B, Pires VP, Keller PM (2018)
    J Clin Microbiol 56: e01492-17
  29. A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors.
    Hartmann J, Münch RC, Freiling RT, Schneider IC, Dreier B, Samukange W, Koch, J, Seeger MA, Plückthun A, Buchholz CJ (2018)
    Mol Ther Methods Clin Dev 10: 128-143
  30. Quantitative imaging flow cytometry of Legionella-infected Dictyostelium reveals the impact of retrograde trafficking on pathogen vacuole composition.
    Welin A, Weber S, Hilbi H (2018)
    Appl Environ Microbiol 84: e00158-18
  31. Detection limit of Mycobacterium chimaera in water samples for monitoring medical device safety: insights from a pilot experimental series.
    Schreiber PW, Köhler N, Cervera R, Hasse B, Sax H, Keller PM (2018)
    J Hosp Infect 99: 284-289
  32. Detection of respiratory bacterial pathogens causing atypical pneumonia by multiplex Lightmix® RT-PCR.
    Wagner K, Springer B, Imkamp F, Opota O, Greub G, Keller PM. (2018)   
    Int J Med Microbiol 308: 317-323
  33. Different Types of Heater-Cooler Units and Their Risk of Transmission of Mycobacterium chimaera During Open-Heart Surgery: Clues From Device Design.
    Kuehl R, Banderet F, Egli A, Keller PM, Frei R, Döbele T, Eckstein F, Widmer AF (2018)
    Infect Control Hosp Epidemiol 39: 834-840
  34. Comparison of Löwenstein-Jensen and BACTEC MGIT 960 culture for Mycobacterium tuberculosis in people living with HIV.
    Hongler J, Musaazi J, Ledergerber B, Eberhard N, Sekaggya-Wiltshire C, Keller PM, Fehr J, Castelnuovo B (2018)
    HIV Med 19: 654-661
  35. Influence of skin disinfection prior removal of perineural catheter on bacterial colonization, contamination and local inflammation: a prospective randomized study.
    Blumenthal S, Zbinden R, Mandic S, Rüst CA, Aguirre J, Borgeat A (2018)
    Minerva Anestesiol 84: 319-327
  36. A novel RT-PCR for the detection of Helicobacter pylori and identification of clarithromycin resistance mediated by mutations in the 23S rRNA gene.
    Redondo JR, Keller PM, Zbinden R, Wagner K. (2018)
    Diagn Microbiol Infect Dis 90: 1-6
  37. High-throughput screening of bacterial pathogens in clinical specimens using 16S rDNA qPCR and fragment analysis.
    Wagner K, Springer B, Pires VP, Keller PM (2018)
    Diagn Microbiol Infect Dis: Epub ahead of print
  38. Increased Pathogen Identification in Vascular Graft Infections by the Combined Use of Tissue Cultures and 16S rRNA Gene Polymerase Chain Reaction.
    Ajdler-Schaeffler E, Scherrer AU, Keller PM, Anagnostopoulos A, Hofmann M, Rancic Z, Zinkernagel AS, Bloemberg GV, Hasse BK; and the VASGRA Cohort (2018)
    Front Med (Lausanne) 5: 169
  39. A cluster of scedosporiosis in lung transplant candidates and recipients: The Zurich experience and review of the literature.
    Abela IA, Murer C, Schuurmans MM, Schmitt JW, Muller F, Imkamp F, Mueller NJ, Benden C (2018)
    Transpl Infect Dis 20: e12792
  40. Ureaplasma and Mycoplasma in kidney allograft recipients-A case series and review of the literature.
    Gerber L, Gaspert A, Braghetti A, Zwahlen H, Wüthrich R, Zbinden R, Mueller N, Fehr T (2018)
    Transpl Infect Dis 20: e12937
  41. Whisky, microwave or hairdryer? Exploring the most efficient way to reduce bacterial colonisation on contaminated toothbrushes.
    Patcas R, Zbinden R, Schätzle M, Schmidlin PR, Zehnder M (2018)
    Br Dent J 225: 1007-1010

  42. Legionella quorum sensing and its role in pathogen-host interactions.
    Personnic N, Striednig B, Hilbi H (2018)
    Curr Opin Microbiol 41: 29-35
  43. Membrane transporter research in times of countless structures.
    Seeger MA (2018)
    Biochim Biophys Acta 1860: 804-808
  44. The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance.
    Luthra S, Rominski A, Sander P (2018)
    Front Microbiol 9: 2179
  45. Acanthamoeba and Dictyostelium as cellular models for Legionella infection.
    Swart AL, Harrison CF, Eichinger L, Steinert M, Hilbi H (2018)
    Front Cell Infect Microbiol 8: 61
  46. Improving the quality and workflow of bacterial genome sequencing and analysis: paving the way for a Switzerland-wide molecular epidemiological surveillance platform.
    Egli A, Blanc DS, Greub G, Keller PM, Lazarevic V, Lebrand A, Leib S, Neher RA, Perreten V, Ramette A, Schrenzel J, Stephan R, Wagner K, Wuethrich D, Xenarios I (2018)
    Swiss Med Wkly 148: w14693
  47.  The large GTPase atlastin controls ER remodeling around a pathogen vacuole.
    Steiner B, Weber S, Kaech A, Ziegler U, Hilbi H (2018)
    Commun Integr Biol 11: 1-5
  48. Analysis of Legionella metabolism by pathogen vacuole proteomics.
    Manske C, Finsel I, Hoffmann C, Hilbi H (2018)
    In Meth. Mol. Biol. 1841, Microbial proteomics. Becher, D. (ed.), Springer Press; pp. 59-76.

    Comment Letters
  49. Urban transmission of tuberculosis in China.
    Keller PM (2018)
    Comment on: Internal migration and transmission dynamics of tuberculosis in Shanghai, China: an epidemiological, spatial, genomic analysis.
    Yang, Chongguang et al (2018)
    The Lancet Infect Dis 18: 706-707
  50. Re: Zweifel et al.: Clinical and histopathologic findings in disseminated Mycobacterium chimera infection after cardiothoracic surgery (Ophthalmology. 2017;124:178-188).
    Zweifel SA, Keller PM, Hasse B, Barthelmes D, Böni C (2018)
    Ophthalmology 125: e33-e34



  1. Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study.
    van Ingen J, Kohl TA, Kranzer K, Hasse B, Keller P, Szafrańska AK, Hillemann D, Chand M, Schreiber PW, Sommerstein R, Berger C, Genoni M, Rüegg C, Troillet N, Widmer AF, Becker SL, Herrmann M, Eckmanns T, Haller S, Höller C, Debast SB, Wolfhagen MJ, Hopman  J, Kluytmans J, Langelaar M, Notermans DW, ten Oever J, van den Barselaar P, Vonk AB, Vos MC, Ahmed N, Brown T, Crook D, Lamagni T, Phin N, Smith G, Zambon M, Serr A, Götting T, Ebner W, Thürmer A, Utpatel C, Spröer C, Bunk B, Nübel U, Bloemberg GV, Böttger EC, Niemann S, Wagner D, Sax H (2017)
    Lancet Infect Dis 17: 1033-1041
  2. Development of a novel lead that targets M. tuberculosis polyketide synthase 13.
    Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR,  Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC (2017)
    Cell 170: 249-259
  3. Structure-based design and synthesis of apramycin-paromomycin analogues. Importance of the configuration at the 6′-position and differences between the 6′-amino and hydroxy series.
    Mandhapati AR, Yang G, Kato T, Shcherbakov D, Hobbie SN, Vasella A, Böttger EC, Crich D (2017)
    J Am Chem Soc 139: 14611-14619  
  4. A model to improve and standardize clinical breakpoints for antimicrobial susceptibility testing using forecast probabilities.
    Blöchliger N, Keller P, Böttger EC, Hombach M (2017)
    J Antimicrob Chemother 72: 2553-2561
  5. Rapid detection of ESBL, carbapenemases, MRSA and other important resistance phenotypes within 6h to 8h by automated disk diffusion antibiotic susceptibility testing.
    Hombach M, Jetter M, Keller P, Blöchliger N, Kolesnik-Goldmann N, Böttger EC (2017)
    J Antimicrob Chemother 72: 3063-3069
  6. Fully automated disc diffusion for rapid antibiotic susceptibility test results: a proof-of-principle study.
    Hombach M, Jetter M, Blöchliger N, Kolesnik-Goldmann N, Böttger EC (2017)
    J Antimicrob Chemother 72: 1659-1688
  7. N6’, N6’’’ and O4' modifications to neomycin affect ribosomal selectivity without compromising antibacterial activity.
    Sati G, Scherbakov D, Hobbie S, Vasella A, Böttger EC, Crich D (2017)
    ACS Infect Dis 3: 368-377
  8. Structure-activity relationships of spectinamide antituberculosis agents; a dissection of ribosomal inhibition and native efflux avoidance contributions.
    Liu J, Bruhn D, Lee R, Zheng Z, Janusic T, Scherbakov D, Scherman M, Boshoff H, Das S, Raskesh K, Waidyarachchi S, Brewer T, Gracia B, Yang L, Bollinger J, Robertson G, Meibohm B, Lenaerts A, Ainsa J, Böttger EC, Lee R (2017)
    ACS Infect Dis 3: 72-88
  9. Lipoprotein glycosylation by protein-O-mannosyltransferase (MAB_1122c) contributes to low cell envelope permeability and antibiotic resistance in Mycobacterium abscessus.
    Becker K, Haldimann K, Selchow P, Reinau LM, Dal Molin M, Sander P (2017)
    Frontiers Microbiology 8: 2123
  10. Effect of β-lactamase production and β-lactam instability on MIC testing results of Mycobacterium abscessus.
    Rominski A, Schultess B, Müller D, Keller P, Sander P (2017)
    J Antimicrob Chemother 72: 3070-3078
  11. Elucidation of Mycobacterium abscessus aminoglycoside and capreomycin resistance by targeted deletion of three putative resistance genes.
    Rominski A, Selchow P, Becker K, Brülle JK, Dal Molin M, Sander P (2017)
    J Antimicrob Chemother 72: 2191-2200
  12. Intrinsic rifamycin resistance of Mycobacterium abscessus is mediated by ADP-ribosyltransferase MAB_0591.
    Rominski A, Roditscheff A, Selchow P, Böttger EC, Sander P (2017)
    J Antimicrob Chemother 72: 376-384
  13. Chloroquine enhances the antimycobacterial activity of isoniazid and pyrazinamide by reversing inflammation-induced macrophage efflux.
    Matt U, Selchow P, Dal Molin M, Strommer S, Sharif O, Schilcher K, Andreoni F, Stenzinger A, Zinkernagel AS, Zeitlinger M, Sander P, Nemeth J (2017)
    Int J Antimicrob Agents 50: 55-62
  14. Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
    Bärlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA, Hilbi H (2017)
    Nat Commun 8: 1543
  15. ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila.
    Steiner B, Swart AL, Welin A, Weber S, Personnic N, Kaech A, Freyre C, Ziegler U, Klemm RW, Hilbi H (2017)
    EMBO Rep 18: 1817-1836
  16. Legionella pneumophila modulates mitochondrial dynamics to trigger metabolic repurposing of infected macrophages.
    Escoll P, Song OR, Viana F, Steiner B, Lagache T, Olivo-Marin JC, Impens F, Brodin P, Hilbi H, Buchrieser C (2017)
    Cell Host Microbe 22: 302-316
  17. Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model.
    Ouertatani-Sakouhi H, Kicka S, Chiriano G, Harrison CF, Hilbi H, Scapozza L, Soldati T, Cosson P (2017)
    PLoS One 12: e0181121
  18. Comparative proteomics of purified pathogen vacuoles correlates intracellular replication of Legionella pneumophila with the small GTPase Rap1.
    Schmölders J, Manske C, Otto A, Hoffmann C, Steiner B, Welin A, Becher D, Hilbi H (2017)
    Mol Cell Proteomics 16: 622-641
  19. Split tasks of asymmetric nucleotide-binding sites in the heterodimeric ABC exporter EfrCD.
    Hürlimann LM, Hohl M, Seeger MA (2017)
    FEBS J 284: 1672-1687
  20. Exploring conformational equilibria of a heterodimeric ABC transporter.
    Timachi MH, Hutter CAJ, Hohl M, Assafa T, Böhm S, Mittal A, Seeger MA and Bordignon E (2017)
    Elife 6: e20236
  21. Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin.
    Kramer L, Renko M, Završnik J, Turk D, Seeger MA, Vasiljeva O, Grütter MG, Turk V, Turk B (2017)
    Theranostics 7: 2806-2821
  22. Mycobacterium smegmatis PafBC is involved in regulation of DNA damage response.
    Olivencia BF, Müller AU, Roschitzki B, Burger S, Weber-Ban E, Imkamp F (2017)
    Sci Rep 7: 13987
  23. Evaluation of the AID carbapenemase line probe assay for rapid detection and identification of carbapenemase genes in Gram-negative bacilli.
    Bloemberg GV, Braun-Kiewnick A, Tedrup J, Meijerink C, Durer E, Ritter C, Keller PM, Hombach M (2017)
    J Antimicrob Chemother 72: 1948-1954
  24. Comparison of phenotypic methods for the detection of penicillinase in Staphylococcus aureus and proposal of a practical diagnostic approach.
    Hombach M, Weissert C, Senn MM, Zbinden R (2017)
    J Antimicrob Chemother 72: 1089-1093
  25. Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus.
    Blodkamp S, Kadlec K, Gutsmann T, Quiblier C, Naim HY, Schwarz S, von Köckritz-Blickwede M (2017)
    Vet Microbiol 200: 52-58
  26. Asymptomatic congenital tuberculosis: A case report.
    Meyer Sauteur PM, Marques-Maggio E, Relly C, Keller PM, Clarenbach CF, Berger C (2017)
    Medicine (Baltimore) 96: e7562
  27. Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study.
    Koehler P, Hamprecht A, Bader O, Bekeredjian-Ding I, Buchheidt D, Doelken G, Elias J, Haase G, Hahn-Ast C, Karthaus M, Kekulé A, Keller P, Kiehl M, Krause SW, Krämer C, Neumann S, Rohde H, La Rosée P, Ruhnke M, Schafhausen P, Schalk E, Schulz K, Schwartz S, Silling G, Staib P, Ullmann A, Vergoulidou M, Weber T, Cornely OA, Vehreschild MJ (2017)
    Int J Antimicrob Agents 49: 218-223

  28. Eukaryotic ribosome assembly, transport and quality control.
    Peña C, Hurt E, Panse VG (2017)
    Nat Struct Mol Biol 24: 689-699
  29. Formation of the Legionella replicative compartment at the crossroads of retrograde trafficking.
    Bärlocher K, Welin A, Hilbi H (2017)
    Front Cell Infect Microbiol 7: 482
  30. Formation of the Legionella-containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics. 
    Steiner B, Weber S, Hilbi H (2017)
    Int J Med Microbiol: Epub ahead of print
  31. Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial Infection.
    Hilbi H, Kortholt A (2017)
    Small GTPases: Epub ahead of print
  32. Intra-species and inter-kingdom signaling of Legionella pneumophila.
    Hochstrasser R, Hilbi H (2017)
    Front Microbiol 8: 79
  33. Mycobacterium tuberculosis drug-resistance testing: challenges, recent developments and perspectives.
    Schön T, Miotto P, Köser CU, Viveiros M, Böttger EC, Cambau E (2017)
    Clin Microbiol Infect 23: 154-160
  34. TBVAC2020: Advancing tuberculosis vaccines from discovery to clinical development.
    Kaufmann SHE, Dockrell HM, Drager N, Ho MM, McShane H, Neyrolles O, Ottenhoff THM, Patel B, Roordink D, Spertini F, Stenger S, Thole J, Verreck FAW, Williams A; TBVAC2020 Consortium (2017)
    Front Immunol 8: 1203

    Book Chapters
  35. Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System.
    Hilbi H, Nagai H, Kubori T, Roy CR (2017)
    Curr Top Microbiol Immunol 413: 221-242



  1. Non-mutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.
    Freihofer P, Akbergenov R, Teo Y, Juskeviciene R, Anderson DI, Böttger EC (2016)
    RNA 22: 1836-1843
  2. Diagnostic molecular mycobacteriology in regions with low tuberculosis endemicity: combining real-time PCR assays for detection of multiple mycobacterial pathogens with line probe assays for identification of resistance mutations.
    Deggim-Messmer V, Bloemberg GV, Ritter C, Voit A, Hömke R, Keller PM, Böttger EC (2016)
    EBioMedicine 9: 228-237
  3. Standard genotyping overestimates transmission of Mycobacterium tuberculosis among immigrants in a low-incidence country.
    Stucki D, Ballif M, Egger M, Furrer H, Altpeter E, Battegay M, Droz S, Bruderer T, Coscolla M, Borrell S, Zürcher K, Janssens JP, Calmy A, Mazza Stalder J, Jaton K, Rieder HL, Pfyffer GE, Siegrist HH, Hoffmann M, Fehr J, Dolina M, Frei R, Schrenzel J, Böttger EC, Gagneux S, Fenner L (2016)
    J Clin Microbiol 54: 1862-1870
  4. Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages.
    Mohanty S, Dal Molin M, Ganguli G, Padhi A, Jena P, Selchow P, Sengupta S, Meuli M, Sander P, Sonawane A (2016)
    Tuberculosis 96: 44-57
  5. Comprehensive proteomic analysis of nitrogen-starved Mycobacterium smegmatis Δpup reveals the impact of pupylation on nitrogen stress response.
    Fascellaro G, Petrera A, Lai ZW, Nanni P, Grossmann J, Burger S, Biniossek ML, Gomez-Auli A, Schilling O, Imkamp F (2016)
    J Proteome Res 15: 2812-2825
  6. Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation.
    Peña C, Schütz S, Fischer U, Chang Y, Panse VG (2016)
    Elife 5: e21755
  7. The heterodimeric ABC transporter EfrCD mediates multidrug efflux in Enterococcus faecalis.
    Hürlimann LM, Corradi V, Hohl M, Bloemberg GV, Tieleman DP, Seeger MA (2016)
    Antimicrob Agents Chemother 60: 5400-5411
  8. The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signaling and gene expression of Legionella pneumophila.
    Schell U, Simon S, Sahr T, Hager D, Albers MF, Kessler A, Fahrnbauer F, Trauner D, Hedberg C, Buchrieser C and Hilbi H (2016)
    Mol Microbiol 99: 778-793
  9. Metabolism of myo-inositol by Legionella pneumophila promotes infection of amoeba and macrophages.
    Manske C, Schell U, Hilbi H (2016)
    Appl Environ Microbiol 82: 5000-5014
  10. Pathway analysis using 13C-glycerol and other carbon tracers reveals bipartite metabolism of Legionella pneumophila.
    Häuslein I, Manske C, Goebel W, Eisenreich W and Hilbi H (2016)
    Mol Microbiol 100: 229-246
  11. In silico driven design and synthesis of rhodanine derivatives as novel antibacterials targeting the enoyl reductase InhA.
    Slepikas L, Chiriano G, Perozzo R, Tardy S, Kranjc-Pietrucci A, Patthey-Vuadens O, Ouertatani-Sakouhi H, Kicka S, Harrison CF, Scrignari T, Perron K, Hilbi H, Soldati T, Cosson P, Tarasevicius E, Scapozza L (2016)
    J Med Chem 59: 10917-10928
  12. IFNs modify the proteome of Legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid.
    Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf H-J, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B (2016)
    PLoS Pathog 12: e1005408
  13. Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.
    Rolando M, Escoll P, Nora T, Botti J, Boitez V, Bedia C, Daniels C, Abraham G, Stogios PJ, Skarina T, Christophe C, Dervins-Ravault D, Cazalet C, Hilbi H, Rupasinghe T, Tull DL, McConville MJ, Ong SY, Hartland EL, Codogno P, Levade T, Naderer T, Savchenko A, Buchrieser C (2016)
    Proc Natl Acad Sci USA 113: 1901-1906
  14. Legionella shows a diverse secondary metabolism dependent on a single Sfp-type phosphopantetheinyl transferase.
    Tobias NJ, Ahrendt T, Schell U, Miltenberger M, Hilbi H, Bode H B (2016)
    PeerJ 4: e2720
  15. Delamanid and bedaquiline resistance in Mycobacterium tuberculosis ancestral Beijing genotype causing XDR-TB in a tibetan refugee.
    Hoffmann H, Kohl TA, Hofmann-Thiel S, Merker M, Beckert P, Jaton K, Nedialkova L, Sahalchyk E, Rothe T, Keller PM, Niemann S (2016)
    Am J Resp Crit Care Med 193: 337-340
  16. Relative contribution of biological variation and technical variables to zone diameter variations of disc diffusion susceptibility testing.
    Hombach M, Ochoa C, Maurer FP, Pfiffner T, Böttger EC, Furrer R (2016)
    J Antimicrob Chemother 71: 141-151
  17. Evaluation of the Bruker MALDI Biotyper for the identification of fastidious Gram-negative rods.
    Schulthess B, Bloemberg GV, Zbinden A, Mouttet F, Zbinden, R, Böttger EC, Hombach M (2016)
    J Clin Microbiol 54: 543-548
  18. Performance of Copan WASP for Routine Urine Microbiology.
    Quiblier C*, Jetter M*, Rominski M, Mouttet F, Böttger EC, Keller PM*, Hombach M* (2016)
    J Clin Microbiol 54: 585-592
  19. Detection of Helicobacter pylori in head and neck cancer patients: Results from a prospective comparative study combining serology, PCR, and rapid urease test.
    Morand GB, Fellmann J, Laske RD, Weisert JU, Soltermann A, Zbinden R, Probst R, Huber GF (2016)
    Head Neck 38: 769-774
  20. Optimal length of cultivation time for isolation of Propionibacterium acnes in suspected bone and joint infections is more than 7 days.
    Bossard DA, Ledergerber B, Zingg PO, Gerber C, Zinkernagel AS, Zbinden R, Achermann Y (2016)
    J Clin Microbiol 54: 3043-3049
  21. Prosthetic vascular graft infections: bacterial cultures from negative-pressure-wound-therapy foams do not improve diagnostics.
    Scherrer AU, Bloemberg G, Zbinden R, Zinkernagel AS, Fuchs C, Frauenfelder S, Rancic Z, Mayer D, Hasse B; VASGRA Cohort (2016)
    J Clin Microbiol 54: 2190-2193
  22. Bacteriophages as potential treatment for urinary tract infections.
    Sybesma W, Zbinden R, Chanishvili N, Kutateladze M, Chkhotua A, Ujmajuridze A, Mehnert U, Kessler TM (2016)
    Front Microbiol 7: 465
  23. Outbreak investigation for toxigenic Corynebacterium diphtheriae wound infections in refugees from Northeast Africa and Syria in Switzerland and Germany by whole genome sequencing.
    Meinel DM, Kuehl R, Zbinden R, Boskova V, Garzoni C, Fadini D, Dolina M, Blümel B, Weibel T, Tschudin-Sutter S, Widmer AF, Bielicki JA, Dierig A, Heininger U, Konrad R, Berger A, Hinic V, Goldenberger D, Blaich A, Stadler T, Battegay M, Sing A, Egli A (2016)
    Clin Microbiol Infect 22:1003

  24. Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a TBNET/RESIST-TB consensus Statement.
    Dominguez J, Böttger EC, Cirillo D, Cobelens F, Eisenach KD, Gagneux S, Hillemann D, Horsburgh R,Molina-Moya B, Niemann S, Tortoli E, Whitelaw A, Lange C (2016)
    Int J Tuberc Lung Dis 20: 24-42
  25. Subversion of retrograde trafficking by translocated pathogen effectors.
    Personnic N, Bärlocher K, Finsel I, Hilbi H (2016)
    Trends Microbiol 24: 450-462
  26. M. tuberculosis lipoproteins in virulence and immunity: fighting with a double-edged sword.
    Becker K, Sander P (2016)
    FEBS Lett: 590: 3800-3819

    Comment Letters
  27. Comment on: Delamanid susceptibility testing of Mycobacterium tuberculosis using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system.
    Imkamp F, Keller PM, Böttger EC (2016)
    J Antimicrob Chemother 71: 3624
  28. Lipase Processing of Complex Lipid Antigens.
    Sander P, Becker K, Molin MD (2016)
    Cell Chem Biol 23: 1044-1046

    Book Chapters
  29. Inflammasome recognition and regulation of the Legionella flagellum.
    Schell U, Simon S, Hilbi H (2016)
    Curr Top Microbiol Immunol 397: 161-181
  30. Identification of anti-infective compounds using amoebae.
    Harrison CF, Hilbi H  (2016)
    In: Host - pathogen interaction: microbial metabolism, pathogenicity and anti-infectives. Unden, G. Thines, E. & Schüffler, A. (eds). Wiley-Blackwell Press; pp. 139-152
  31. ABC Exporters from a Structural Perspective.
    Seeger MA, Bordignon E, Hohl M (2016)
    In: ABC Transporters – 40 years on. George, A.M. (ed). Springer; pp. 65-84


  1. Aminomethyl spectinomycins as novel therapeutics for drug resistant respiratory tract and sexually transmitted bacterial infections.
    Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahmand YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, Lee RE (2015)
    Sci Transl Med 7: 288ra75
  2. The Resistant-Population Cutoff (RCOFF): a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations.
    Valsesia G, Hombach M, Maurer FP, Courvalin P, Roos M, Böttger EC (2015)
    J Clin Microbiol 53: 1806-1811
  3. Phosphatidylinositol 4-phosphate and phosphatidyl-inositol 3-phosphate regulate phagolysosome biogenesis.
    Jeschke A, Zehethofer N, Lindner B, Krupp J, Schwudke D, Haneburger I, Jovic M, Backer JM, Balla T, Hilbi H and Haas A (2015)
    Proc Natl Acad Sci USA 112: 4636-4641
  4. Amoebae-based screening reveals a novel family of compounds restricting intracellular Legionella.
    Harrison CF, Chiriano G, Finsel I, Manske C, Hoffmann C, Steiner B, Kranjc A, Pattey-Vuadens O, Kicka S, Trofimov V, Ouertatani-Sakouhi H, Soldati T, Scapozza L and Hilbi H (2015)
    ACS Infect Dis 1: 327-338
  5. Inter-kingdom signaling by the Legionella quorum sensing molecule LAI-1 inhibits cell migration through an IQGAP1/CDC42/ARHGEF9-dependent pathway.
    Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C and Hilbi H (2015)
    PLoS Pathog 11: e1005307
  6. Influence of 4'-O-glycoside constitution and configuration on ribosomal selectivity of paromomycin.
    Matsushita T, Chen W, Juskeviciene R, Youjin T, Shcherbakov D, Vasella A, Böttger EC, Crich D (2015)
    J Am Chem Soc 137: 7706-7717
  7. Synthesis and antiribossomal, activities of 4’-0-, 6’-0-,4’’,6’’-0-derivatives in the kanamycin series reveal differing target selectivity patterns between the 4.5- and 4.6- series of disubstituted 2-deoxystreptamine classes of aminoglycoside antibiotics.
    Kato T, Yang G, Youjin T, Juskeviciene R, Perez-Fernandez D, Shinde HM, Salian S, Bernet B, Vasella A, Böttger EC, Crich D (2015)
    ACS Infect Dis 1: 479-486
  8. In vitro and in vivo evaluation of synergism between anti-tubercular spectinamides and non-classical tuberculosis antibiotics.
    Bruhn DF, Schermann M, Liu J, Shcherbakov D, Meibohm B, Böttger EC, Lenaerts AJ, Lee RE (2015)
    Sci Rep 5: 13985
  9. Determination of MIC distribution and epidemiological cut-off values for bedaquiline and delamanid in Mycobacterium tuberculosis using MGIT 960/ TB eXiST.
    Keller P, Hömke R, Ritter C, Valsesia G, Bloemberg GV, Böttger EC (2015)
    Antimicrob Agents Chemother 59: 4352-4355
  10. Effect of application of a PVP-iodine solution before and during subgingival ultrasonic instrumentation on post-treatment bacteremia: A randomized single-center placebo-controlled clinical trial.
    Sahrmann P, Manz A, Attin T, Zbinden R, Schmidlin PR (2015)
    J Clin Periodontol 42: 632-639
  11. Health-care associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery.
    Kohler P, Kuster SP, Bloemberg GV, Schulthess B, Frank M, Tanner FC, Rössle M, Böni C, Falk V, Wilhelm MJ, Sommerstein R, Achermann Y, ten Oever J, Debast SB, Wolfhagen MJHM, Brandon Bravo Bruinsma GJ, Vos MC, Bogers A, Serr A, Beyersdorf F, Sax H, Böttger EC, Weber R, van Ingen J, Wagner D, Hasse B (2015)
    Eur Heart J 36: 2745-2753
  12. Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis.
    Bloemberg GV, Keller P, Stucki D, Trauner A, Borrell S, Latshang T, Coscolla N, Rothe T, Hömke R, Ritter C, Feldmann J, Schulthess B, Gagneux S, Böttger EC (2015)
    N Engl J Med 373: 1986-1988
  13. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy.
    Zbinden A, Zbinden R, Berger C, Arlettaz R (2015)
    Neonatology 107: 56-59
  14. Clonality and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus at the University Hospital Zurich, Switzerland between 2012 and 2014.
    Seidl K, Leimer N, Marques MP, Furrer A, Holzmann-Bürgel A, Senn G, Zbinden R, Zinkernagel AS (2015)
    Ann Clin Microb Antimicro 14: 1-7
  15. Standardization of operator-dependent variables affecting precision and accuracy of the disk diffusion method for antibiotic susceptibility testing.
    Hombach M, Maurer FP, Pfiffner T, Böttger EC, Furrer R (2015)
    J Clin Microbiol 53: 3864-3869
  16. Evaluation of the RAPIDEC® CARBA NP test for the detection of carbapenemases in Enterobacteriaceae.
    Hombach M, von Gunten B, Castelberg C, Bloemberg GV (2015)
    J Clin Microbiol 53: 3828-3833
  17. A transporter motor taken apart: flexibility in the nucleotide binding domains of a heterodimeric ABC exporter.
    Bukowska MA, Hohl M, Geertsma ER, Hürlimann LM, Grütter MG, and Seeger MA (2015)
    Biochemistry 54: 3086–3099
  18. Adrenergic antagonists restrict replication of Legionella.
    Harrison CF, Kicka S, Kranjc A, Finsel I, Chiriano G, Ouertatani-Sakouhi H, Soldati T, Scapozza L and Hilbi H (2015)
    Microbiology 161: 1392-1406
  19. Fluorine-decoupled carbon spectroscopy for the determination of configuration at fully substituted, trifluoromethyl- and perfluoroalkyl-bearing carbons: comparison with (19)f-(1)h heteronuclear overhauser effect spectroscopy.
    Mandhapati AR, Kato T, Matsushita T, Ksebati B, Vasella A, Böttger EC, Crich D (2015)
    J Org Chem 80: 1754-1763
  20. Bicistronic mRNAs to enhance membrane protein overexpression.
    Marino J, Hohl M, Seeger MA, Zerbe O, Geertsma ER (2015)
    J Mol Biol 427: 943-954
  21. Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis.
    Sander P, Clark S, Petrera A, Vilaplana C, Meuli M, Selchow P, Zelmer A, Mohanan D, Andreu N, Rayner E, Dal Molin M, Bancroft GJ, Johansen P, Cardona PJ, Williams A, Böttger EC (2015)
    Vaccine 33: 1353-1359
  22. XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.
    Oishi N, Duscha S, Boukari H, Meyer M, Xie J, Wei G, Roschitzki B, Böttger EC, Schacht J (2015)
    Cell Death and Disease 6: e1763
  23. Revisiting susceptibility testing in multidrug resistant tuberculosis by a standardized quantitative phenotypic assessment in a European multicenter study.
    Cambau E, Viveiros M, Machado D, Raskine L, Ritter C, Tortoli E, Mattys V, Hoffner S, Richter E, Perez-del-Molino L, Cirillo D, van Soolingen D, Böttger EC (2015)
    J Antimicrob Chemother 70: 686-696
  24. Evaluation of carbapenemase screening and confirmation tests in Enterobacteriaceae and development of a practical diagnostic algorithm.
    Maurer F, Castelberg C, Quiblier C, Bloemberg G, Hombach M (2015)
    J Clin Microbiol 53: 95-104
  25. A mutation associated with clofazimine and bedaquiline cross-resistance in MDRTB following bedaquiline treatment.
    Somoskovi A, Bruderer V,Hömke R, Bloemberg GV, Böttger EC (2015)
    Eur Respir J 45: 554-557
  26. Aminoglycoside modifying enzymes determine the innate susceptibility to aminoglycoside antibiotics in rapidly growing mycobacteria.
    Maurer F, Bruderer V, Castelberg C, Ritter C, Scherbakov D, Bloemberg G, Böttger E (2015)
    J Antimicrob Chemother 70: 1412-1419
  27. A statistical approach for determination of disk-diffusion based cut-off values for systematic characterization of wild-type and non-wild-type bacterial populations in antimicrobial susceptibility testing.
    Valsesia G, Roos M, Böttger EC, Hombach M (2015)
    J Clin Microbiol 2015 53: 1812-1822
  28. Prolonged outbreak of Mycobacterium chimaera infection after open chest heart surgery.
    Sax H, Bloemberg G, Hasse B, Sommerstein R, Kohler P, Achermann Y, Rössle M, Falk V, Kuster SP, Böttger EC, Weber R (2015)
    Clin Infect Dis 61: 67-75

  29. Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones.
    Finsel I and Hilbi H (2015)
    Cell Microbiol 17: 935-950
  30. Purification and proteomics of pathogen-modified vacuoles and membranes.
    Herweg JA, Hansmeier N, Otto A, Geffken AC, Subbarayal P, Prusty BK, Becher D, Hensel M, Schaible UE, Rudel T and Hilbi H (2015)
    Front Cell Infect Microbiol 5: 48
  31. Subversion of cell autonomous immunity and cell migration by Legionella pneumophila effectors.
    Simon S and Hilbi H (2015)
    Front Immunol 6: 477
  32. Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014.
    Whole Mycobacteria Cell Vaccines for Tuberculosis Summary Group: Kaufmann S, Bloom B, Brosch R, Cardona P-J, Dockrell H, Fritzell B, Grode L, Hanekom W, Hokey D, Levin M, Martin C, Sander P, Scriba T, Shaligram U, Tameris M, von Reyn F, Walker B, Weiner J, White RG, Schrager L (2015)
    Vaccine 33: 3047-3055
  33. Pupylation-dependent and independent proteasomal degradation in mycobacteria.
    Imkamp F, Ziemski M, Weber-Ban E (2015)
    Biomol Concepts 6: 285-301

    Book Chapters
  34. Aggregatibacter, Capnocytophaga, Eikenella, Kingella, Pasteurella, and other fastidious or rarely encountered Gram-negative rods.
    R. Zbinden (2015)
    In Manual of Clinical Microbiology 11th Edition, 652-666
    Jorgensen JH, Pfaller MA, Carroll KC, Funke G, Landry ML, Richter SS, Warnock DW (eds) ASM press, Washington DC, USA


  1. Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.
    Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ (2014)
    Nat Med 20: 152-158
  2. 4’-O-substitutions determine selectivity of aminoglycoside antibiotics.
    Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC (2014)
    Nat Commun 5: 3112
  3. Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.
    Lepore M, Kalinicenko A, Colone A, Paleja B, Singhal A, Tschumi A, Lee B, Poidinger M, Zolezzi F, Quagliata L, Sander P, Newell E, Bertoletti A, Terracciano L, De Libero G, Mori L (2014)
    Nat Commun 5: 3866
  4. Identification and evaluation of improved 4’-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next generation aminoglycoside antibiotics.
    Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC (2014)
    mBio 5: e01827-14
  5. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.
    Mori M, Moraca F, Deodato D, Ferraris DM, Selchow P, Sander P, Rizzi M, Botta M (2014)
    Bioorg Med Chem Lett 24: 2508-2511
  6. Importance of the 6‘-hydroxy group and its configuration for apramycin activity.
    Mandhapati AR, Shcherbakov D, Duscha S, Vasella A, Böttger EC and Crich D (2014)
    ChemMedChem 9: 2074-2083
  7. Synthesis, antiribosomal and antibacterial activity of 4’-O-glycopyranosyl paromomycin aminoglycoside antibiotics.
    Chen W, Matsushita T, Shcherbakov D, Boukari H, Vasella A, Böttger EC and Crich D (2014)
    Med Chem Commun 5: 1179–1187
  8. In-vivo efficacy of apramycin in murine infection models.
    Meyer M, Freihofer P, Scherman M, Teague J, Lenaerts A, Böttger EC (2014)
    Antimicrob Agents Chemother 58: 6938-6941
  9. Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
    Hohl M, Hürlimann LM, Böhm S, Schöppe J, Grütter MG, Bordignon E, Seeger MA (2014)
    Proc Natl Acad Sci U S A 111: 11025-11030
  10. Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.
    Eicher T, Seeger MA, Anselmi C, Zhou W, Brandstätter L, Verrey F, Diederichs K, Faraldo-Gómez JD, Pos KM (2014)
    Elife 3: 03145
  11. Phosphorylation signaling through the Legionella quorum sensing histidine kinases LqsS and LqsT converges on the response regulator LqsR.
    Schell U, Kessler A and Hilbi H (2014)
    Mol Microbiol 92: 1039–1055
  12. Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator.
    Simon S, Wagner M, Rothmeier E, Müller-Taubenberger A and Hilbi H (2014)
    Cell Microbiol 16: 977–992
  13. The Legionella longbeachae Icm/Dot substrate SidC selectively binds PtdIns(4)P with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions.
    Dolinsky S, Haneburger I, Hannemann M, Cichy A, Itzen A and Hilbi H (2014)
    Infect Immun 82: 4021-4033
  14. BCG Δzmp1 vaccine induces enhanced antigen specific immune responses in cattle.
    Khatri B, Whelan A, Clifford D, Petrera A, Sander P, Vordermeier HM (2014)
    Vaccine 32: 779-784
  15. Evaluation of the AID ESBL line probe assay for rapid detection of extended spectrum β-lactamases (ESBL) and KPC carbapenamase genes in Enterobacteriaceae.
    Bloemberg GV, Polsfuss S, Meyer V, Böttger EC, Hombach M (2014)
    J Antimicrob Chemother 69: 85-90
  16. Streptococcus tigurinus small-colony variants causing prosthetic joint infection: characterization by comparative whole-genome analyses.
    Zbinden A, Quiblier C, Hernandez D, Herzog K, Bodler P, Senn MM, Gizard Y, Schrenzel J, François P (2014)
    J Clin Microbiol 52: 467-474
  17. Evaluation of the AID TB Resistance line probe assay for rapid detection of genetic alterations associated with Mycobacterium tuberculosis drug resistance.
    Ritter C, Lucke K, Sirgel FA, Warren RW, van Helden PD, Böttger EC, Bloemberg GV (2014)
    J Clin Microbiol 52: 940-946
  18. Transmission of multidrug-resistant tuberculosis in low-incidence setting, Switzerland, 2006 to 2012.
    Somoskovi A, Helbling P, Deggim V, Hömke R, Ritter C, Böttger EC (2014)
    Euro Surveill 19(11)
  19. Erm(41)-dependent inducible resistance to azithromycin and clarithromycin in clinical isolates of Mycobacterium abscessus.
    Maurer F, Castelberg C, Quiblier C, Böttger E, Somoskövi A (2014)
    J. Antimicrob Chemother 69: 1559-1563
  20. Evaluation of the Bruker MALDI Biotyper for identification of Gram-positive rods - development of a diagnostic algorithm for the clinical laboratory.
    Schulthess B, Bloemberg G, Zbinden R, Böttger E, Hombach M (2014)
    J Clin Microbiol 52: 1089-1097
  21. Infections with the tick-borne bacterium "Candidatus Neoehrlichia mikurensis" mimic non-infectious conditions in patients with B cell malignancies or autoimmune diseases.
    Grankvist A, Andersson PO, Mattsson M, Sender M, Vaht K, Höper L, Sakiniene E, Trysberg E, Stenson M, Fehr J, Pekova S, Bogdan C, Bloemberg G, Wennerås C (2014)
    Clin Infect Dis 58: 1716-1722
  22. Lack of antimicrobial bactericidal activity in Mycobacterium abscessus.
    Maurer F, Bruderer V, Ritter C, Castelberg C, Bloemberg GV, Böttger EC (2014)
    Antimicrob Agents Chemother 58: 3828-3836
  23. Validation of antibiotic susceptibility testing guidelines in a routine clinical microbiology laboratory exemplifies general key challenges in setting clinical breakpoints.
    Hombach M, Courvalin P, Böttger EC (2014)
    Antimicrob Agents Chemother 58: 3921-3926
  24. Use of the Bruker MALDI Biotyper for the identification of molds in the clinical mycology laboratory.
    Schulthess B, Ledermann R, Mouttet F, Zbinden A, Bloemberg GV, Böttger EC, Hombach M (2014)
    J Clin Microbiol 52: 2797-2803
  25. Antibiotic susceptibility of Clostridium difficile is similar worldwide over two decades despite widespread use of broad-spectrum antibiotics: an analysis done at the University Hospital of Zurich.
    Büchler AC, Rampini SK, Stelling S, Ledergerber B, Peter S, Schweiger A, Ruef C, Zbinden R, Speck RF (2014)
    BMC Infect Dis 14: 607
  26. Candida species distribution and antifungal susceptibility testing according to EUCAST and new vs. old CLSI clinical breakpoints: a six-year prospective candidemia survey from the Fungal Infection Network of Switzerland (FUNGINOS).
    Orasch C, Marchetti O, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Rossi M, Pfyffer G, Ruef C, Fehr J, Zbinden R, Calandra T, Bille J; The Fungal Infection Network of Switzerland (FUNGINOS) (2014)
    Clin Microbiol Infect 20: 698-705
  27. Postsurgical wound infections due to rapidly growing myciobacteria in Swiss medical tourists following cosmetic surgery in Latin America between 2012 and 2014.
    Maurer FP, Castelberg C, von Braun A, Wolfensberger A, Bloemberg GV, Böttger EC, Somoskovi A (2014)
    Euro Surveill 19: 37
  28. Integrating forecast probabilities in antibiograms - a way to guide antimicrobial prescriptions more reliably?
    Maurer FP, Courvalin P, Böttger EC, Hombach M (2014)
    J Clin Microbiol 52: 3674-3684
  29. A type IV-translocated Legionella cysteine phytase counteracts intracellular growth restriction by phytate.
    Weber S, Stirnimann CU, Wieser M, Frey D, Meier R, Engelhardt S, Li X, Capitani G, Kammerer RA and Hilbi H (2014)
    J Biol Chem 289: 34175-34188

  30. Pupylation as a signal for proteasomal degradation in bacteria.
    Striebel F, Imkamp F, Ozcelik D, Weber-Ban E (2014)
    Biochim Biophys Acta 1843: 103-113
  31. Metabolism of the vacuolar pathogen Legionella and implications for virulence.
    Manske C and Hilbi H (2014)
    Front Microbiol 4: 125
  32. Beyond Rab GTPases: Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility and infection.
    Hilbi H, Rothmeier E, Hoffmann C and Harrison CF (2014)
    Small GTPases 5: 1-6

    Comment Letters
  33. Reply to the comment of Blakemore and Alland to "Described diagnostic inconsistencies were observed with an obsolete version of the Xpert MTB/RIF Assay and are unlikely to recur in the current version of the assay"
    Somoskovi A, Bloemberg GV (2014)
    J Clin Microbiol 52: 705
  34. Reply to the comment of Blaich and Frei to "Performance of the Xpert MTB/RIF Assay on Nonrespiratory Specimens and Its Accuracy for Detection of Rifampin Resistance in a Low-Prevalence Setting"
    Deggim V, Somoskovi A, Bloemberg GV (2014)
    J Clin Microbiol 52: 707
  35. Reply to Raoult.
    Wennerås C, Bloemberg G, Bogdan C (2014)
    Clin Infect Dis 59: 1042-1043

    Book Chapters
  36. Life cell imaging of phosphoinositide dynamics during Legionella infection. 
    Weber S and Hilbi H (2014)
    In Meth. Mol. Biol. 1197, Pathogen-host interactions: method and protocols. Vergunst, A. C. and O´Callaghan, D. (eds.), Springer Press; pp. 153-167.
  37. Bacterial lipoproteins: biogenesis, virulence/pathogenicity and trafficking.
    Tokuda H*, Sander P*, Lee BL*, Okuda S, Grau T, Tschumi A, Brülle JK, Kurokawa K and Nakayama H (2014)
    In: Bacterial membranes: Structural and molecular biology. Remaut, H., Fronzes, R. (eds). Caister Academic Press, Norfolk, UK, p. 133 – 177.


  1. Lymph node targeting of BCG vaccines amplifies CD4 and CD8 T-cell responses and protection against Mycobacterium tuberculosis.
    Waeckerle-Men Y, Bruffaerts N, Liang Y, Jurion F, Sander P, Kündig TM, Huygen K, Johansen P (2013)
    Vaccine 31: 1057-1064
  2. HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis.
    Fenner L, Egger M, Bodmer T, Furrer H, Ballif M, Battegay M, Helbling P, Fehr , Gsponer T, Rieder HL, Zwahlen M, Hoffmann M, Bernasconi E, Cavassini M, Calmy A, Dolina M, Frei R, Janssens JP, Borrell S, Stucki D, Schrenzel J, Böttger EC, Gagneux S (2013)
    PLoS Genet 9: e1003318
  3. The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks.
    Sirgel FA, Warren RM, Böttger EC, Klopper M, Victor TC, van Helden PD (2013)
    PLoS One 8: e59414
  4. Mutation in the C-Di-AMP Cyclase dacA Affects Fitness and Resistance of Methicillin Resistant Staphylococcus aureus.
    Dengler V, McCallum N, Kiefer P, Christen P, Patrignani A, Vorholt JA, Berger-Bächi B, Senn MM (2013)
    PLoS One 8: e73512
  5. Close geographic association of human neoehrlichiosis and tick populations carrying Candidatus Neoehrlichia mikurensis in Eastern Switzerland.
    Maurer F, Keller PM, Beuret CM, Joha C, Achermann Y, Gubler J, Birchler D, Karrer U, Fehr J, Zimmerli L, Bloemberg GV (2013)
    J Clin Microbiol 51: 169-176
  6. A well preserved culprit.
    Maurer F, Marques Maggio E, Roth TN, Kuster SP, Bloemberg GV (2013)
    Clin Infect Dis 56: 747-748
  7. The critical influence of the intermediate category on interpretation errors in revised EUCAST and CLSI antimicrobial susceptibility testing guidelines.
    Hombach M, Böttger EC, Roos M (2013)
    Clin Microbiol Infect 19: E59-71
  8. Influence of clinical breakpoint changes from CLSI 2009 to EUCAST 2011 AST guidelines on multi drug resistance rates of Gram-negative rods.
    Hombach M, Wolfensberger A, Kuster SP, Böttger EC (2013)
    J Clin Microbiol 51: 2385-2387
  9. Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera.
    Achermann Y, Rössle M, Hoffmann M, Deggim V, Kuster S, Zimmermann DR, Bloemberg GV, Hombach M, Hasse B (2013)
    J Clin Microbiol 51: 1769-1773
  10. Consequences of revised CLSI and EUCAST guidelines for antibiotic susceptibility patterns of Extended Spectrum Beta-Lactamase and AmpC Beta-Lactamase producing clinical Enterobacteriaceae isolates.
    Hombach M, Mouttet B, Bloemberg GV (2013)
    J Antimicrob Chemother 68: 2092-2098
  11. Identification of Gram-positive cocci using MALDI-TOF MS: comparison of different preparation methods and implementation of a practical algorithm for routine diagnostics.
    Schulthess B, Brodner K, Bloemberg G, Zbinden R, Böttger E, Hombach M (2013)
    J Clin Microbiol 51: 1834-1840
  12. High level resistance to isoniazid and ethionamide in multidrug resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations.
    Machado D, Perdigão J, Ramos J, Couto I, Portugal I, Ritter C, Böttger EC, Viveiros M (2013)
    J Antimicrob Chemother 68: 1728-1732
  13. Evaluation of COBAS(R) TaqMan MTB for direct detection of Mycobacterium tuberculosis complex in comparison with the COBAS(R) Amplicor MTB.
    Bloemberg GV, Voit A, Ritter C, Deggim V, Böttger EC (2013)
    J Clin Microbiol 51: 2112-2117
  14. Integrating the Xpert MTB/RIF assay in a diagnostic work flow for rapid detection of Mycobacterium tuberculosis in a low prevalence area.
    Deggim V, Somoskövi A, Voit A, Böttger EC, Bloemberg GV (2013)
    J Clin Microbiol 51: 2396-2399
  15. Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Switzerland: sampling only invasive isolates does not allow a representative description of the local diversity of clones.
    Senn L, Basset P, Greub G, Prod'hom G, Frei R, Zbinden R, Gaia V, Balmelli C, Pfyffer GE, Mühlemann K, Zanetti G, Blanc DS (2013)
    Clin Microbiol Infect 19: E288-290
  16. Drug susceptibility distributions in slowly growing non-tuberculous mycobacteria using MGIT 960 TB eXiST.
    Hombach M, Somoskövi A, Hömke R, Ritter C, Böttger EC (2013)
    Int J Med Microbiol 303: 270-276
  17. Lipoproteins of slow-growing Mycobacteria carry three fatty acids and are N-acylated by apolipoprotein N-acyltransferase BCG_2070c.
    Brülle JK, Tschumi A, Sander P (2013)
    BMC Microbiol 13: 223
  18. Change of antibiotic susceptibility testing guidelines from CLSI to EUCAST: Influence on cumulative hospital antibiograms.
    Wolfensberger A, Sax H, Weber R, Zbinden R, Kuster SP, Hombach M (2013)
    PLOS ONE 8: e79130
  19. Standardisation of disk diffusion results for antibiotic susceptibility testing using the Sirscan automated zone reader.
    Hombach M, Zbinden R, Böttger EC (2013)
    BMC Microbiol 13: 225

  20. The mitochondrion: A perpetrator of acquired hearing loss.
    Böttger EC, Schacht J (2013)
    Hear Res 303: 12-19

  21. Comment Letter
  22. Transmission of M. abscessus in patients with cystic fibrosis.
    Böttger EC (2013)
    Lancet 382: 503-504


  1. Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.
    Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC (2012)
    Proc Natl Acad Sci USA 109: 10984-10989
  2. Comparison of EUCAST and CLSI screening parameters for the detection of extended spectrum beta-lactamase (ESBL) production in clinical Enterobacteriaceae isolates.
    Polsfuss S, Bloemberg GV, Giger J, Meyer V, Hombach M (2012)
    J Antimicrob Chemother 67: 159-166
  3. Automated quantitative drug susceptibility testing of nontuberculous mycobacteria using MGIT960 / EpiCenter TBeXIST.
    Lucke K, Hombach M, Friedel U, Ritter C, Böttger EC (2012)
    J Antimicrob Chemother 67: 154-158
  4. Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response.
    Dengler V, Stutzmann-Meier P, Heusser R, Kupferschmied P, Fazekas J, Friebe S, Burger-Staufer S, Majcherczyk PA, Moreillon P, Berger-Bächi B, McCallum N (2012)
    FEMS Microbiol Lett 333: 109-120
  5. Phenylethyl-butyrate enhances the potency of second-line drugs against clinical isolates of M. tuberculosis.
    Grau T, Selchow P, Tigges M, Burri R, Gitzinger M, Böttger EC, Fussenegger M, Sander P (2012)
    Antimicrob Agents Chemother 56: 1142-1145
  6. Functional analyses of mycobacterial lipoprotein diacylglyceryl transferase and comparative secretome analysis of a mycobacterial lgt mutant.
    Tschumi A, Grau T, Albrecht D, Rezwan M, Antelmann H, Sander P (2012)
    J Bacteriol 194: 3938-3949
  7. Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates.
    Petrera A, Amstutz B, Gioia M, Hähnlein J, Baici A, Selchow P, Ferraris DM, Rizzi M, Sbardella D, Marini S, Coletta M, Sander P (2012)
    Biol Chem 393: 631-640
  8. Opposing roles of Sigma B and Sigma B-controlled SpoVG in the global regulation of esxA in Staphylococcus aureus.
    Schulthess B, Bloes DA, Berger-Bächi B (2012)
    BMC Microbiol 12: 17
  9. Effects of clinical breakpoint changes in CLSI guidelines 2010/2011 and EUCAST guidelines 2011 on antibiotic susceptibility test reporting of Gram-negative bacilli.
    Hombach M, Bloemberg GV, Böttger EC (2012)
    J. Antimicrob Chemother 67: 622-632
  10. Streptococcus tigurinus, a novel member of the Streptococcus mitis group, causes invasive infections.
    Zbinden A, Müller NJ, Tarr PE, Eich G, Schulthess B, Bahlmann AS, Keller PM, Bloemberg GV (2012)
    J Clin Microbiol 50: 2969-2973
  11. Important role for Mycobacterium tuberculosis UvrD1 in pathogenesis and persistence apart from its function in nucleotide excision repair.
    Houghton J, Townsend C, Williams AR, Rodgers A, Rand L, Walker KB, Böttger EC, Springer B, Davis EO (2012)
    J Bacteriol 194: 2916-2923
  12. Mycobacterium tuberculosis transmission in a low-incidence country: role of immigration and HIV infection.
    Fenner L, Gagneux S, Helbling P, Battegay M, Rieder H, Pfyffer G, Zwahlen M, Furrer H, Siegrist H, Fehr J, Dolina M, Calmy A, Stucki D, Jaton K, Janssens JP, Mazza Stalder J, Bodmer T, Ninet B, Böttger EC, Egger M (2012)
    J Clin Microbiol 50: 388-395
  13. Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcome.
    Fenner L, Gagneux S, Janssens JP, Fehr J, Cavassini M, Hoffman M, Bernasconi E, Schrenzel J, Bodmer T, Böttger EC, Helbling P, Egger M (2012)
    PLoS One 7: e34186
  14. Mycobacterium tuberculosis population structure determines the outcome of genetic based second-line drug resistance testing.
    Streicher E, Bergval I, Dheda K, Böttger EC, Gey van Pitius N, Bosman M, Coetzee G, Anthony R, van Helden PD, Victor TC, Warren RM (2012)
    Antimicrob Agents Chemother 56: 2420-2427
  15. Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.
    Fenner L, Egger M, Bodmer T, Altpeter E, Zwahlen M, Jaton K, Pfyffer GE, Borrell S, Dubuis O, Bruderer T, Siegrist HH, Furrer H, Calmy A, Fehr J, Stalder JM, Ninen B, Böttger EC, Gagneux S (2012)
    Antimicrob Agents Chemother 56: 3047-3053
  16. Evaluation of a diagnostic flow-chart for detection and confirmation of extended spectrum beta-lactamases (ESBL) in Enterobacteriaceae.
    Polsfuss S, Bloemberg GV, Giger J, Meyer V, Böttger EC, Hombach M (2012)
    Clin Microbiol Infect 18: 1194-1204
  17. gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis.
    Sirgel FA, Warren RM, Streicher EM, Victor TC, van Helden PD, Böttger EC (2012)
    J Antimicrob Chemother 67: 1088-1093
  18. Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis.
    Sirgel FA, Tait M, Warren RM, Streicher EM, Böttger EC, van Helden PD, Gey van Pittius NC, Coetzee G, Hoosain EY, Chabula-Nxiweni M, Hayes C, Victor TC, Trollip A (2012)
    Microb Drug Resist 18: 193-197
  19. embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis.
    Sirgel FA, Warren RM, Streicher EM, Victor TC, van Helden PD, Böttger EC (2012)
    Chemotherapy 58: 358-363
  20. Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxy and amino groups.
    Salian S, Matt T, Akbergenov R, Harish S, Meyer M, Duscha S, Shcherbakov D, Bernet BB, Vasella A, Westhof E, Böttger EC (2012)
    Antimicrob Agents Chemother 56: 6104-6108
  21. Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41) methylase.
    Maurer F, Rüegger V, Ritter C, Bloemberg GV, Böttger EC (2012)
    J Antimicrob Chemother 67: 2606–2611
  22. Streptococcus tigurinus sp. nov., isolated from blood of patients with endocarditis, meningitis and spondylodiscitis.
    Zbinden A, Müller NJ, Tarr PE, Spröer C, Keller PM, Bloemberg GV (2012)
    Int J Syst Evol Microbiol 62: 2941-2945

    Comment Letter
  23. Interferon-gamma release assays and the risk of developing active tuberculosis.
    Böttger EC (2012)
    Am J Respir Crit Care Med 185: 786-787