|Education and working experience||
- In vitro display technologies for the selection of binding-proteins against membrane protein targets.
- Structure and dynamics of G protein-coupled receptors.
- Macromolecular X-ray crystallography.
- Directed evolution of proteins.
- SNSF BRIDGE proof of concept grant
Synthetic single domain antibodies for the conformational trapping of membrane proteins.
Zimmermann I, Egloff P, Hutter CA, Arnold FM, Stohler P, Bocquet N, Hug MN, Huber S, Siegrist M, Hetemann L, Gera J, Gmür S, Spies P, Gygax D, Geertsma ER, Dawson RJ, Seeger MA (2018)
Elife 7: e34317
Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding.
Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F (2016)
Proc Natl Acad Sci USA 113: E3629-3638
Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts.
Schütz M, Schöppe J, Sedlák E, Hillenbrand M, Nagy-Davidescu G, Ehrenmann J, Klenk C, Egloff P, Kummer L, Plückthun A (2016)
Sci Rep 6: 21508
Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in E. coli
Egloff P., Hillenbrand M., Klenk C., Batyuk A., Heine P., Balada S., Schlinkmann K. M., Scott D.J., Schütz M., Plückthun A. (2014)
Proceedings of the National Academy of Science
Generation of disposable ligand columns for rapid purifications of large quantities of homogeneous and functional G protein-coupled receptors.
Egloff P., De Luigi M., Heine P., Balada S. Plückthun A. (2014)
Protein Expression and Purification
Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies.
Scott D.J., Kummer L., Egloff P., Bathgate R.A., Plückthun A (2014).
Biochimica et Biophysica Acta
Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system
Schubert M., Bleuler-Martinez S., Butschi A., Wälti M.A., Egloff P., Stutz K., Yan S., Collot M., Mallet J.M., Wilson I.B., Hengartner M.O., Aebi M., Allain F.H., Künzler M. (2012)