Dr. Iwan Zimmermann

Dr. Iwan Zimmermann

Leader sybody platform

Tel.: +41 44 634 59 86



Curriculum vitae

Education and working experience
2012-2013 Postdoctoral Research Assistant, Department of Biochemistry, University of Zurich (Prof. R. Dutzler)
2008-2012 Ph.D. Student, Department of Biochemistry, University of Zurich (Prof. R. Dutzler)
2002-2008 Undergraduate and Master Studies of Biochemistry, Focus on Chemistry, University of Zurich
1996-2001 Kantonsschule Glarus, Glarus, Focus on Chemistry and Biology

Research interests

  • Structure and function of membrane proteins involved in neural signaling (e.g. Ion channels and neurotransmitter transporters)
  • Selection of affinity reagents against membrane proteins and method development to perform these selections
  • Macromolecular X-ray crystallography


Research grants

  • BioEntrepreneur-Fellowship of the University of Zurich


Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach.
Kaur H, Hartmann JB, Jakob RP, Zahn M, Zimmermann I, Maier T, Seeger MA, Hiller S (2019)
J Biomol NMR: Epub ahead of print

Engineered peptide barcodes for in-depth analyses of binding protein libraries.
Egloff P, Zimmermann I, Arnold FM, Hutter CAJ, Morger D, Opitz L, Poveda L, Keserue HA, Panse C, Roschitzki B, Seeger MA (2019)
Nat Methods 16: 421-428

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor.
Bräuer P, Parker JL, Gerondopoulos A, Zimmermann I, Seeger MA, Barr FA, Newstead S (2019)
Science 363: 1103-1107

Synthetic single domain antibodies for the conformational trapping of membrane proteins.
Zimmermann I, Egloff P, Hutter CA, Arnold FM, Stohler P, Bocquet N, Hug MN, Huber S, Siegrist M, Hetemann L, Gera J, Gmür S, Spies P, Gygax D, Geertsma ER, Dawson RJ, Seeger MA (2018)
Elife 7: e34317

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels.
Bertozzi C, Zimmermann I, Engeler S, Hilf RJ, Dutzler R (2016)
Plos Biol 14: e1002393

Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations.
Zimmermann I, Marabelli A, Bertozzi C, Sivilotti LG, Dutzler R (2012)
PLoS Biol 10: e1001429

Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC.
Zimmermann I, Dutzler R (2011)
PLoS Biol 9: e1001101

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel.
Hilf R, Bertozzi C, Zimmermann I, Reiter A, Trauner D, Dutzler R (2010)
Nat Struct Mol Biol 17: 1330-1336

X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter.
Warmuth S, Zimmermann I, Dutzler R (2009)
Structure 17: 538-546

Binding of 9-methylguanine to [cis-Ru(2,2'-bpy)2]2+: First X-ray structure of a cis-bis purine complex of ruthenium.
Zobi F, Hohl M*, Zimmermann I*, Alberto R (2004)
Inorg Chem 43: 2771-2772
*equal contribution